All Phenotypes Med24<tm1Rgr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Med24^tm1Rgr/Med24^tm1Rgr	involves: 129X1/SvJ * C57BL/6	MGI:2655545
hm2	Med24^tm1Rgr/Med24^tm1Rgr	involves: 129X1/SvJ * C57BL/6 * CD-1	MGI:2655546

Allelic Composition	Med24^tm1Rgr/Med24^tm1Rgr
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med24^tm1Rgr mutation (0 available); any Med24 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77765 )

• on a hybrid 129X1/SvJ x C57BL/6 background, homozygotes are obtained at a slightly lower frequency at E8.5-E10.5; only dead or degenerated mutant embryos are found after E9.5

• Background Sensitivity: embryonic survival is extended to E10.0 after three backcrossings to the CD1 outbred strain

embryo

abnormal embryo development ( J:77765 )

• at E9.0, mutant embryos are too tiny and poorly differentiated to undergo further analysis

decreased embryo size ( J:77765 )

• at E9.0, mutant embryos are severely reduced relative to wild-type embryos

growth/size/body

decreased embryo size ( J:77765 )

• at E9.0, mutant embryos are severely reduced relative to wild-type embryos

cellular

abnormal cell physiology ( J:77765 )

• mutant MEFs fail to proliferate well under conventional culture conditions, suggesting a defective autonomous cell growth program

• in culture, fibroblastoid cells recovered from E9.0 mutant embryos display attenuated functions of a wide variety of transcriptional activators on ectopic reporters

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77765 )

• Background Sensitivity: embryonic survival is extended to E10.0 after three backcrossings to the CD1 outbred strain

cardiovascular system

abnormal blood vessel morphology ( J:77765 )

• at E10.0, the vascular system, including both great vessels and collateral small vessels, is malformed and narrow, as typified in the aorta and labyrinthine placenta

abnormal dorsal aorta morphology ( J:77765 )

• at E10.0, the mutant dorsal aortas remain divided

abnormal placental labyrinth vasculature morphology ( J:77765 )

• at E10.0, the placental labyrinth vasculature is poorly developed, restricting the nutritional supply to the embryo

heart hypoplasia ( J:77765 )

• at E10.0, homozygotes display cardiac hypoplasia that leads to severe heart failure

ventricular hypoplasia ( J:77765 )

trabecula carnea hypoplasia ( J:77765 )

• at E10.0, mutant hearts show poor ventricular trabeculation, that is even more severe than that detected at E9.5

thin ventricular wall ( J:77765 )

• at E10.0, homozygotes exhibit very thin ventricular walls

abnormal heartbeat ( J:77765 )

• weak heartbeats are detected at E10.0

embryo

abnormal placental labyrinth vasculature morphology ( J:77765 )

• at E10.0, the placental labyrinth vasculature is poorly developed, restricting the nutritional supply to the embryo

abnormal embryo development ( J:77765 )

• at E10.0, mutant embryos appear severely hypoplastic

abnormal neural tube morphology ( J:77765 )

• at E10.0, the mutant neural tube is abnormally thin and displays irregular mitotic events

open neural tube ( J:77765 )

• at E10.0, the neural tube is open

abnormal embryonic erythropoiesis ( J:77765 )

• at E10.0, some nucleated red cells are present indicating that yolk sac hematopoiesis is only partially blocked

hematopoietic system

abnormal embryonic erythropoiesis ( J:77765 )

• at E10.0, some nucleated red cells are present indicating that yolk sac hematopoiesis is only partially blocked

anemia ( J:77765 )

• at E10.0, live mutant embryos are moderately to severely anemic

muscle