All Phenotypes Dcc<kanga> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dcc^kanga/Dcc^kanga	involves: AKR * C3H	MGI:2446654
ht2	Dcc^kanga/Dcc^tm1Wbg	involves: 129X1/SvJ * AKR * C3H	MGI:3665462

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:80430 )

• mild to severe inability to remain upright

abnormal gait ( J:80430 )

• hopping-like gait

nervous system

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the ipsilateral lateral funiculus but not into the ventral funiculus

absent corpus callosum ( J:80430 )

absent hippocampal commissure ( J:80430 )

• absent hippocampal commissure

abnormal pyramidal decussation morphology ( J:80430 )

• no axons cross the midline at the pyramidal decussation instead axons spread medially to laterally just before the decussation then split into medial and lateral bundles

abnormal pontine nuclei morphology ( J:80430 )

• absence of pontine nuclei from the hindbrain

abnormal corticospinal tract morphology ( J:80430 )

• absent from the dorsal funiculus

• no axons cross the midline at the pyramidal decussation instead axons spread medially to laterally just before the decussation then split into medial and lateral bundles

• the abnormal medial bundle extends ipsilaterally into the ventral regions of the ipsilateral lateral funiculus

cellular

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the ipsilateral lateral funiculus but not into the ventral funiculus

Allelic Composition	Dcc^kanga/Dcc^tm1Wbg
Genetic Background	involves: 129X1/SvJ * AKR * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcc^kanga mutation (1 available); any Dcc mutation (76 available)
Dcc^tm1Wbg mutation (1 available); any Dcc mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:80430 )

nervous system

abnormal axon guidance ( J:80430 )

• axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus

absent corpus callosum ( J:80430 )

absent hippocampal commissure ( J:80430 )

• absent hippocampal commissure

abnormal pyramidal decussation morphology ( J:80430 )

• no axons cross the midline at the pyramidal decussation

abnormal corticospinal tract morphology ( J:80430 )

• absent from the dorsal funiculus

cellular

abnormal axon guidance ( J:80430 )

• axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus

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