skeleton
• in vitro osteoclastogenesis from bone marrow-derived monocyte/macrophage lineage cells is impaired, especially at suboptimal concentrations of RANKL and M-CSF, compared to similarly treated wild-type cells
• however, osteoblast growth and differentiation are normal
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• at 6 months
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• at 6 months, osteoclast function is decreased compared to in wild-type mice
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• at 6 months, mice exhibit a slight increase in metaphyses compared to wild-type mice
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• at 6 months, bone volume to tissue volume is increased compared to in wild-type mice
• however, bone volume to tissue volume is normal at 1.5 and 3 months of age
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• at 6 months, mice exhibit a slight increase in trabecular bones compared to wild-type mice
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• at 6 months, mice exhibit slight increases in metaphyses and trabecular bones compared to wild-type mice
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immune system
• in vitro osteoclastogenesis from bone marrow-derived monocyte/macrophage lineage cells is impaired, especially at suboptimal concentrations of RANKL and M-CSF, compared to similarly treated wild-type cells
• however, osteoblast growth and differentiation are normal
|
• at 6 months
|
• at 6 months, osteoclast function is decreased compared to in wild-type mice
|
hematopoietic system
• in vitro osteoclastogenesis from bone marrow-derived monocyte/macrophage lineage cells is impaired, especially at suboptimal concentrations of RANKL and M-CSF, compared to similarly treated wild-type cells
• however, osteoblast growth and differentiation are normal
|
• at 6 months
|
• at 6 months, osteoclast function is decreased compared to in wild-type mice
|
cellular
• in vitro osteoclastogenesis from bone marrow-derived monocyte/macrophage lineage cells is impaired, especially at suboptimal concentrations of RANKL and M-CSF, compared to similarly treated wild-type cells
• however, osteoblast growth and differentiation are normal
|