All Phenotypes Dkc1<tm2Bsl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dkc1^tm2Bsl/Dkc1^tm2Bsl	involves: 129/Sv * C57BL/6	MGI:3778163
cn2	Dkc1^tm2Bsl/Y Tg(Gata1-cre)1Sho/0	involves: 129/Sv * C57BL/6 * CD-1	MGI:3778209
cn3	Dkc1^tm2Bsl/Dkc1⁺ Tg(Gata1-cre)1Sho/0	involves: 129/Sv * C57BL/6 * CD-1	MGI:3778211
ot4	Dkc1^tm2Bsl/Y	involves: 129/Sv * C57BL/6	MGI:3778164

Allelic Composition	Dkc1^tm2Bsl/Dkc1^tm2Bsl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1^tm2Bsl mutation (0 available); any Dkc1 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80494 )

• mice are viable and fertile and indistinguishable from wild-type littermates

Allelic Composition	Dkc1^tm2Bsl/Y Tg(Gata1-cre)1Sho/0
Genetic Background	involves: 129/Sv * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1^tm2Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:80494 )

• no male embryos are recovered at E7.5 when the floxed allele is derived from the mother

• same phenotype is observed when EIIa-cre transgenic males are used

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:80494 )

• no live embryos are recovered at E9.5 and most have been resorbed at E12.5, with inheritance of the maternally derived mutant allele

• same phenotype is observed when EIIa-cre transgenic males are used

embryo

increased trophectoderm apoptosis ( J:80494 )

• after E7.5, apoptotic nuclei are observed in the trophectoderm

abnormal embryo development ( J:80494 )

• at E8.5 and E9.5, embryos appear morphologically disorganized relative to wild-type

failure of initiation of embryo turning ( J:80494 )

• at E8.5 or E9.5, embryos do not show signs of axial rotation

embryonic growth arrest ( J:80494 )

• after E7.5, embryos become developmentally growth arrested

decreased embryo size ( J:80494 )

• at E8.5 and E9.5, embryos are visibly smaller than littermates

trophectoderm cell degeneration ( J:80494 )

• at E8.5 and E9.5, degeneration within the trophectoderm becomes more extensive

growth/size/body

decreased embryo size ( J:80494 )

• at E8.5 and E9.5, embryos are visibly smaller than littermates

reproductive system

transmission ratio distortion ( J:80494 )

• females with the deletion on the paternally-inherited allele are unable to transmit the deletion to offspring; only homozygous Dkc1⁺, cre transgene-negative male and female offspring are obtained when females heterozygous for the deleted allele are crossed to wild-type males

cellular

increased trophectoderm apoptosis ( J:80494 )

• after E7.5, apoptotic nuclei are observed in the trophectoderm

Allelic Composition	Dkc1^tm2Bsl/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1^tm2Bsl mutation (0 available); any Dkc1 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80494 )

• mice are viable and fertile and indistinguishable from wild-type littermates

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