Phenotypes associated with this allele

• Allele Symbol: Cbl^tm2Hua
• Allele Name: targeted mutation 2, Hua Gu
• Allele ID: MGI:2446506
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cbl^tm2Hua/Cbl^tm2Hua Cblb^tm1Hua/Cblb^tm1Hua Tg(Lck-cre)I57Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * ICR	MGI:2652089

Genotype
MGI:2652089

cn1

• Allelic Composition: Cbl^tm2Hua/Cbl^tm2Hua; Cblb^tm1Hua/Cblb^tm1Hua; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:80427 )

• female animals were moribund at 12 weeks of age; male animals were moribund at 16 weeks of age

cardiovascular system

abnormal blood vessel morphology ( J:80427 )

• thickened intima, thickened tunica aventitia and severe T cell infilatration

growth/size/body

decreased body weight ( J:80427 )

• weight gain lagged behind wild-type controls after 3 weeks of age

enlarged spleen ( J:80427 )

hematopoietic system

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation

enlarged spleen ( J:80427 )

extramedullary hematopoiesis ( J:80427 )

abnormal T cell morphology ( J:80427 )

• enlarged T cells

immune system

enlarged spleen ( J:80427 )

abnormal T cell morphology ( J:80427 )

• enlarged T cells

abnormal immune system physiology ( J:80427 )

• lymphadenopathy

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation

dermatitis ( J:80427 )

• subacute dermatitis

liver/biliary system

liver fibrosis ( J:80427 )

integument

dermatitis ( J:80427 )

• subacute dermatitis

cellular

increased T cell proliferation ( J:80427 )

• in response to anti-CD3 stimulation