Phenotypes associated with this allele

• Allele Symbol: Prodh^m1Kara
• Allele Name: mutation 1, Maria Karayiorgou
• Allele ID: MGI:2446517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prodh^m1Kara/Prodh^m1Kara	involves: C57BL/6J * PRO/Re	MGI:2450118

Genotype
MGI:2450118

hm1

• Allelic Composition: Prodh^m1Kara/Prodh^m1Kara
• Genetic Background: involves: C57BL/6J * PRO/Re

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased aspartic acid level ( J:54012 )

• aspartate levels were decreased in the hypothalamus and frontal cortex, but not in the amygdala or hippocampus

decreased gamma-aminobutyric acid level ( J:54012 )

• gamma-aminobutyric acid (GABA) levels were decreased in the hypothalamus and frontal cortex, but not in the amygdala or hippocampus

decreased glutamic acid level ( J:54012 )

• glutamate levels were decreased in the hypothalamus, but not in the amygdala or hippocampus

increased proline level ( J:54012 )

• proline levels were increased in the hypothalamus, amygdala, hippocampus, and frontal cortex

increased circulating proline level ( J:54012 )

• hyperprolinemia; 7-fold increase in plasma proline levels relative to wild-type littermates, F3 generation

growth/size/body

decreased body weight ( J:54012 )

• 2-3 month old males weighed ~10% less than wildtype littermates

behavior/neurological

increased startle reflex ( J:54012 )

• attenuated sensorimotor gating measured by pre-pulse inhibition

• not a result of abnormal hearing

• no open field locomotion abnormalities detected

nervous system

nervous system phenotype ( J:54012 )

N • gross brain morphology was normal

N • glycine levels were unaffected in all brain regions examined