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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il3tm1Glli
targeted mutation 1, Stephen J Galli
MGI:2446538
Summary 8 genotypes


Genotype
MGI:5431921
hm1
Allelic
Composition		 Il3tm1Glli/Il3tm1Glli
Genetic
Background		 B6.129S2-Il3tm1Glli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:145518 )
• large lymphoid aggregates surround but do not penetrate many islets




Genotype
MGI:3586340
hm2
Allelic
Composition		 Il3tm1Glli/Il3tm1Glli
Genetic
Background		 either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell differentiation ( J:80500 )
• decreased induction of mast cells in bone marrow
• decreased mast cell hyperplasia in intestine, effect in jejunum less significant in BALB/c than C57BL/6 background
decreased susceptibility to type IV hypersensitivity reaction ( J:80640 )
• less intense cellular infiltrates
• less edema
• fewer and smaller intraepidermal abscesses
increased susceptibility to parasitic infection ( J:80500 )
• delayed expulsion of parasites - Strongyloides venezuelensis
• parasites fail to induce increases in basophils

hematopoietic system
abnormal mast cell differentiation ( J:80500 )
• decreased induction of mast cells in bone marrow
• decreased mast cell hyperplasia in intestine, effect in jejunum less significant in BALB/c than C57BL/6 background

cellular
abnormal mast cell differentiation ( J:80500 )
• decreased induction of mast cells in bone marrow
• decreased mast cell hyperplasia in intestine, effect in jejunum less significant in BALB/c than C57BL/6 background




Genotype
MGI:5431918
cx3
Allelic
Composition		 Csf2tm1Mlg/Csf2tm1Mlg
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
Genetic
Background		 B6.129S-Csf2tm1Mlg Il3tm1Glli Ifngtm1TsIfngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Mlg mutation (1 available); any Csf2 mutation (35 available)
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:145518 )
N
• significantly reduced fasting blood sugar, to levels similar to controls
• improved glucose tolerance

neoplasm

nervous system




Genotype
MGI:3586342
cx4
Allelic
Composition		 Csf2tm1Dran/Csf2tm1Dran
Il3tm1Glli/Il3tm1Glli
Genetic
Background		 B6.129S2-Csf2tm1Dran Il3tm1Glli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Dran mutation (0 available); any Csf2 mutation (35 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased eosinophil cell number ( J:67404 )
• increase in circulating eosinophiles but not in bone marrow
abnormal leukocyte physiology ( J:83086 )
• defective phagocytosis of apoptotic cells
decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )
• dramatically reduced response to secondary challenge in tests for contact hypersensitivity
• very reduced cellular infiltrates
• much reduced edema
• very little keratinocyte activation
increased anti-double stranded DNA antibody level ( J:83086 )
• increased level of anti double stranded DNA
glomerulonephritis ( J:83086 )
• appears after 8 months of age
• B and T cell aggregates in the renal pelvis and liver
lung inflammation ( J:67404 )
• extensive lymphoid hyperplasia around both airways and veins

respiratory system
lung inflammation ( J:67404 )
• extensive lymphoid hyperplasia around both airways and veins
abnormal surfactant secretion ( J:83086 )
• accumulation of surfactant in intra-alveolar spaces

renal/urinary system
glomerulonephritis ( J:83086 )
• appears after 8 months of age
• B and T cell aggregates in the renal pelvis and liver

hematopoietic system
increased eosinophil cell number ( J:67404 )
• increase in circulating eosinophiles but not in bone marrow
abnormal leukocyte physiology ( J:83086 )
• defective phagocytosis of apoptotic cells




Genotype
MGI:5431917
cx5
Allelic
Composition		 Csf2tm1Mlg/Csf2tm1Mlg
Il3tm1Glli/Il3tm1Glli
Genetic
Background		 B6.129S2-Csf2tm1Mlg Il3tm1Glli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Mlg mutation (1 available); any Csf2 mutation (35 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:145518 )
• large lymphoid aggregates surround and penetrate many islets
• islets are reduced in size
decreased pancreatic beta cell number ( J:145518 )
• reduced number of insulin secreting beta cells

homeostasis/metabolism
hyperglycemia ( J:145518 )
• fasting hyperglycemia in most but not all 8 month old mice
• significantly increased peak blood sugar after glucose challenge
impaired glucose tolerance ( J:145518 )
• significantly increased peak blood sugar after glucose challenge




Genotype
MGI:3586343
cx6
Allelic
Composition		 Csf2tm1Dran/Csf2tm1Dran
Il3tm1Glli/Il3tm1Glli
Genetic
Background		 C.129S2-Csf2tm1Dran Il3tm1Glli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Dran mutation (0 available); any Csf2 mutation (35 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased eosinophil cell number ( J:67404 )
• increase in circulating eosinophiles but not in bone marrow
decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )
• dramatically reduced response to secondary challenge in tests for contact hypersensitivity
• very reduced cellular infiltrates
• much reduced edema
• very little keratinocyte activation
lung inflammation ( J:67404 )
• accumulation of surfactant in intra-alveolar spaces
• extensive lymphoid hyperplasia around both airways and veins

respiratory system
lung inflammation ( J:67404 )
• accumulation of surfactant in intra-alveolar spaces
• extensive lymphoid hyperplasia around both airways and veins
abnormal surfactant secretion ( J:67404 )
• accumulation of surfactant in intra-alveolar spaces

hematopoietic system
increased eosinophil cell number ( J:67404 )
• increase in circulating eosinophiles but not in bone marrow




Genotype
MGI:3586344
cx7
Allelic
Composition		 Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Dran mutation (0 available); any Csf2 mutation (35 available)
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:83086 )
• surviving mice became moribund with time
• most died or had to be euthanized before 14 months of age
postnatal lethality, incomplete penetrance ( J:83086 )
• about 40% of homozygotes died of pneumonia in the first few weeks of life

immune system
increased eosinophil cell number ( J:83086 )
• mild eosinophilia in mice surviving beyond the first few weeks of life
increased IgE level ( J:83086 )
• serum levels increased but not significantly
increased IgG1 level ( J:83086 )
• significantly higher serum IgG1 levels
• non significant increases in serum IgG2b levels
increased inflammatory response ( J:83086 )
• acute and chronic inflammatory reactions found in many organs and tissues

neoplasm
increased B cell derived lymphoma incidence ( J:83086 )
• Lymphoproliferative disease in a high proportion of mice
• develops into B cell lymphomas
increased carcinoma incidence ( J:83086 )
• solid tumors are benign to metastasizing carcinomas
increased ovarian carcinoma incidence ( J:83086 )
• particularly prevalent

hematopoietic system
increased eosinophil cell number ( J:83086 )
• mild eosinophilia in mice surviving beyond the first few weeks of life
increased IgE level ( J:83086 )
• serum levels increased but not significantly
increased IgG1 level ( J:83086 )
• significantly higher serum IgG1 levels
• non significant increases in serum IgG2b levels

endocrine/exocrine glands
increased ovarian carcinoma incidence ( J:83086 )
• particularly prevalent

reproductive system
increased ovarian carcinoma incidence ( J:83086 )
• particularly prevalent




Genotype
MGI:3586341
cx8
Allelic
Composition		 Il3tm1Glli/Il3tm1Glli
KitW/KitW-v
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * WB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il3tm1Glli mutation (1 available); any Il3 mutation (31 available)
KitW mutation (10 available); any Kit mutation (182 available)
KitW-v mutation (10 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:80500 )
• particularly significant delay in expulsion of parasites - Strongyloides venezuelensis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory