Phenotypes associated with this allele

• Allele Symbol: Tg(BGLAP-PTN)1Thg
• Allele Name: transgene insertion 1, Tamotsu Hashimoto-Gotoh
• Allele ID: MGI:2446540
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(BGLAP-PTN)1Thg/Tg(BGLAP-PTN)1Thg	involves: C57BL/6 * DBA/1	MGI:2652098
tg2	Tg(BGLAP-PTN)1Thg/0	involves: C57BL/6 * DBA/1	MGI:2652095

Genotype
MGI:2652098

tg1

• Allelic Composition: Tg(BGLAP-PTN)1Thg/Tg(BGLAP-PTN)1Thg
• Genetic Background: involves: C57BL/6 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral content ( J:80636 )

• increased in females; however, 14 weeks after ovarectomy, bone mineral content was comparable to that of unovarectomized wild-type mice

Genotype
MGI:2652095

tg2

• Allelic Composition: Tg(BGLAP-PTN)1Thg/0
• Genetic Background: involves: C57BL/6 * DBA/1

skeleton

thick neurocranium ( J:80035 )

• increased thickness of calvaria bones

short femur ( J:80035 )

increased bone mineral content ( J:80035 )

• male animals show increased bone mineral content at 15, 25, and 30 weeks of age

abnormal skeletal maturation ( J:80035 )

• reduced rate of bone growth

• absence of pubertal growth spurt

delayed skeletal maturation ( J:80035 )

• extended duration of bone growth (25 weeks)

craniofacial

thick neurocranium ( J:80035 )

• increased thickness of calvaria bones

limbs/digits/tail

short femur ( J:80035 )