immune system
• germinal centers do not form in the spleen
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• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
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• the marginal zone in the spleen is absent and T and B cell areas are variable
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• mature follicular dendritic cells are absent from the mesenteric lymph nodes
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• in most mice only one large spherical mesenteric lymph node is present unlike in wild-type mice that possess a chain of three elongated lymph node segments
• mature follicular dendritic cells are absent from the mesenteric lymph nodes
• unlike in Ltbtm1Kpf homozygotes and wild-type mice, PNA+ B cells do not aggregate but remain scattered
• the reticulum of the deep cortex is uniform and coarser than in wild-type mice and there is no transition to germinal center-like structures
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• cervical lymph nodes could not be identified
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• mice lack brachial, iliac, axillary, inguinal and popliteal lymph nodes
• however, mesenteric and sacral lymph nodes are present
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hematopoietic system
• germinal centers do not form in the spleen
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• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
|
• the marginal zone in the spleen is absent and T and B cell areas are variable
|