All Phenotypes Ltb/Tnf/Lta<tm1Dvk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk	B6.Cg-Ltb/Tnf/Lta^tm1Dvk	MGI:4440881
hm2	Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk	involves: C57BL/6	MGI:3652521
cx3	Mertk^nmf12/Mertk^nmf12 Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk	involves: C57BL/6J	MGI:5287882

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching

increased leukocyte cell number ( J:80616 )

• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity

abnormal spleen morphology ( J:80616 )

• spleen architecture is severely disturbed

• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles

decreased spleen B cell follicle number ( J:80616 )

• absence of polarized B-cell follicles

absent spleen germinal center ( J:80616 )

• do not form germinal centers

absent spleen marginal zone ( J:80616 )

decreased spleen white pulp amount ( J:80616 )

• gradual reduction of white pulp size

decreased IgG level ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants

absent Peyer's patches ( J:80616 )

absent mesenteric lymph nodes ( J:80616 )

absent axillary lymph nodes ( J:80616 )

absent brachial lymph nodes ( J:80616 )

absent inguinal lymph nodes ( J:80616 )

absent popliteal lymph nodes ( J:80616 )

absent lymph nodes ( J:80616 )

increased susceptibility to bacterial infection ( J:80616 )

• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive

• increased susceptibility to Salmonella enterica infection

hematopoietic system

abnormal class switch recombination ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching

increased leukocyte cell number ( J:80616 )

• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity

abnormal spleen morphology ( J:80616 )

• spleen architecture is severely disturbed

decreased spleen B cell follicle number ( J:80616 )

• absence of polarized B-cell follicles

absent spleen germinal center ( J:80616 )

• do not form germinal centers

absent spleen marginal zone ( J:80616 )

decreased spleen white pulp amount ( J:80616 )

• gradual reduction of white pulp size

decreased IgG level ( J:80616 )

• specific IgG antibodies are almost undetectable in SRBC immunized mutants

Allelic Composition	Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Lta^tm1Dvk mutation (1 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased spleen white pulp amount ( J:109621 )

• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts

immune system

decreased spleen white pulp amount ( J:109621 )

• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts

Allelic Composition	Mertk^nmf12/Mertk^nmf12 Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Lta^tm1Dvk mutation (1 available); any Tnf mutation (48 available)
Mertk^nmf12 mutation (1 available); any Mertk mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:175587 )

• at P45 abnormalities are seen across the entire retina

retina photoreceptor degeneration ( J:175587 )

• accelerated degeneration compared to mice homozygous for the Mertk mutation alone

thin retina inner nuclear layer ( J:175587 )

• in the peripheral retina at 3 months of age

thin retina outer nuclear layer ( J:175587 )

• markedly thinned across the entire retina at 3 months of age

nervous system

retina photoreceptor degeneration ( J:175587 )

• accelerated degeneration compared to mice homozygous for the Mertk mutation alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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