All Phenotypes Stam2<tm1Sug> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stam2^tm1Sug
targeted mutation 1, Kazuo Sugamura
MGI:2446571

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stam2^tm1Sug/Stam2^tm1Sug	Not Specified	MGI:3029395
cn2	Stam^tm2Sug/Stam^tm2Sug Stam2^tm1Sug/Stam2^tm1Sug Tg(Lck-cre)I57Jxm/0	involves: 129S4/SvJae * C57BL/6 * ICR	MGI:3029479
cx3	Stam^tm1Sug/Stam^tm1Sug Stam2^tm1Sug/Stam2^tm1Sug	involves: 129S4/SvJae * C57BL/6	MGI:3029474

Allelic Composition	Stam2^tm1Sug/Stam2^tm1Sug
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2^tm1Sug mutation (2 available); any Stam2 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80617 )

• homozygous mice were indistinguishable from controls and exhibited normal lymphocyte responses

Allelic Composition	Stam^tm2Sug/Stam^tm2Sug Stam2^tm1Sug/Stam2^tm1Sug Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2^tm1Sug mutation (2 available); any Stam2 mutation (55 available)
Stam^tm2Sug mutation (1 available); any Stam mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

decreased T cell number ( J:80617 )

• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

immune system

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

decreased T cell number ( J:80617 )

• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

cellular

decreased T cell proliferation ( J:80617 )

• responses to TCR stimulation and cytokines are severely impaired

Allelic Composition	Stam^tm1Sug/Stam^tm1Sug Stam2^tm1Sug/Stam2^tm1Sug
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2^tm1Sug mutation (2 available); any Stam2 mutation (55 available)
Stam^tm1Sug mutation (1 available); any Stam mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:80617 )

• double homozygous embryos die at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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