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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stam2tm1Sug
targeted mutation 1, Kazuo Sugamura
MGI:2446571
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stam2tm1Sug/Stam2tm1Sug Not Specified MGI:3029395
cn2
 		Stamtm2Sug/Stamtm2Sug
Stam2tm1Sug/Stam2tm1Sug
Tg(Lck-cre)I57Jxm/0 		involves: 129S4/SvJae * C57BL/6 * ICR MGI:3029479
cx3
 		Stamtm1Sug/Stamtm1Sug
Stam2tm1Sug/Stam2tm1Sug 		involves: 129S4/SvJae * C57BL/6 MGI:3029474


Genotype
MGI:3029395
hm1
Allelic
Composition		 Stam2tm1Sug/Stam2tm1Sug
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2tm1Sug mutation (2 available); any Stam2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:80617 )
• homozygous mice were indistinguishable from controls and exhibited normal lymphocyte responses




Genotype
MGI:3029479
cn2
Allelic
Composition		 Stamtm2Sug/Stamtm2Sug
Stam2tm1Sug/Stam2tm1Sug
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2tm1Sug mutation (2 available); any Stam2 mutation (56 available)
Stamtm2Sug mutation (1 available); any Stam mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired
decreased T cell number ( J:80617 )
• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

immune system
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired
decreased T cell number ( J:80617 )
• numbers of mature single positive CD4 or CD8 cells were reduced, and peripheral T cell numbers were reduced

cellular
decreased T cell proliferation ( J:80617 )
• responses to TCR stimulation and cytokines are severely impaired




Genotype
MGI:3029474
cx3
Allelic
Composition		 Stamtm1Sug/Stamtm1Sug
Stam2tm1Sug/Stam2tm1Sug
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stam2tm1Sug mutation (2 available); any Stam2 mutation (56 available)
Stamtm1Sug mutation (1 available); any Stam mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:80617 )
• double homozygous embryos die at E11.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory