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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc11a1tm1Mcg
targeted mutation 1, McGill University
MGI:2446573
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc11a1tm1Mcg/Slc11a1tm1Mcg involves: 129S4/SvJae * BALB/c MGI:2677379
ht2
Slc11a1tm1Mcg/Slc11a1s involves: 129S4/SvJae * BALB/c MGI:2679898


Genotype
MGI:2677379
hm1
Allelic
Composition
Slc11a1tm1Mcg/Slc11a1tm1Mcg
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1tm1Mcg mutation (0 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to mycobacterial infection during the early but not the late phase of acquired immunity
• mice were susceptible to early phase infection with BCG, with a maximum bacterial load at 3 weeks and were able to reduce the BCG load by 6 weeks after infection
• mice inoculated with 103 CFUs of Salmonella entriditis had lower splenic bacterial counts after 42 days than 129/Sv mice, which carry Slc11a1




Genotype
MGI:2679898
ht2
Allelic
Composition
Slc11a1tm1Mcg/Slc11a1s
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1s mutation (0 available); any Slc11a1 mutation (40 available)
Slc11a1tm1Mcg mutation (0 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• compound heterozygous mice were susceptible to early phase infection with BCG or L. donovani or S. typhimurium
• mice showed rapid early BCG proliferation, a maximum bacterial load peaking at 3 weeks, and reduction of the BCG load by 6 weeks after infection





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory