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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Gata1-cre)1Sho
transgene insertion 1, Stuart Orkin
MGI:2446599
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Abcb7tm1Mdf/Y
Tg(Gata1-cre)1Sho/0 		either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N) MGI:3629058
cn2
 		Abcb7tm1Mdf/Abcb7+
Tg(Gata1-cre)1Sho/0 		either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N) MGI:3629059
cn3
 		Atrxtm1Rjg/Y
Tg(Gata1-cre)1Sho/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:3696950
cn4
 		Atrxtm1Rjg/Atrx+
Tg(Gata1-cre)1Sho/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:3696951
cn5
 		Etv6tm2Sho/Etv6tm2Sho
Tg(Gata1-cre)1Sho/? 		involves: 129S1/Sv MGI:3056263
cn6
 		Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Gata1-cre)1Sho/? 		involves: 129S1/Sv * 129S6/SvEvTac * CD-1 MGI:3819386
cn7
 		Etv6tm1(RUNX1)Haho/Etv6+
Tg(Gata1-cre)1Sho/0 		involves: 129S1/Sv * C57BL/6 * CD-1 * Swiss Webster MGI:4356080
cn8
 		Smarca1tm1Pick/Y
Tg(Gata1-cre)1Sho/0 		involves: 129S4/SvJae * CD-1 MGI:5427349
cn9
 		Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Gata1-cre)1Sho/0 		involves: 129S4/SvJae * CD-1 MGI:3814709
cn10
 		Dkc1tm1Bsl/Y
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778208
cn11
 		Dkc1tm2Bsl/Y
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778209
cn12
 		Dkc1tm2Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778211
cn13
 		Dkc1tm1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778210
cx14
 		Dkc1tm1.1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778213
cx15
 		Dkc1tm2.1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:3778212


Genotype
MGI:3629058
cn1
Allelic
Composition		 Abcb7tm1Mdf/Y
Tg(Gata1-cre)1Sho/0
Genetic
Background		 either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb7tm1Mdf mutation (1 available); any Abcb7 mutation (13 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:106838 )
• die at or before E6.5 - E7.5; however no excessive iron deposition is seen

embryo
embryonic growth retardation ( J:106838 )
• slightly growth retarded
abnormal ectoplacental cone morphology ( J:106838 )
• hemorrhage and fibrin in the region of the ectoplacental cone

growth/size/body
embryonic growth retardation ( J:106838 )
• slightly growth retarded

cardiovascular system
hemorrhage ( J:106838 )
• around the ectoplacental cone




Genotype
MGI:3629059
cn2
Allelic
Composition		 Abcb7tm1Mdf/Abcb7+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb7tm1Mdf mutation (1 available); any Abcb7 mutation (13 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:106838 )
• die at or before E6.5 - E7.5; however no excessive iron deposition is seen

embryo
embryonic growth retardation ( J:106838 )
• slightly growth retarded
abnormal ectoplacental cone morphology ( J:106838 )
• hemorrhage and fibrin in the region of the ectoplacental cone

growth/size/body
embryonic growth retardation ( J:106838 )
• slightly growth retarded

cardiovascular system
hemorrhage ( J:106838 )
• around the ectoplacental cone




Genotype
MGI:3696950
cn3
Allelic
Composition		 Atrxtm1Rjg/Y
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (78 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:115836 )
• the expected number of males are detected at E8.5 but fewer than expected are found at E9.5 and no males are found after E9.5

embryo
abnormal trophectoderm morphology ( J:115836 )
• dramatic reduction in trophectoderm surrounding the embryo at E8.5
decreased trophoblast giant cell number ( J:115836 )
• reduced numbers of terminally differentiated trophoblast giant cells at E7.5 and E8.5
• defect is in formation of secondary trophoblast cells; however, development of primary cells is similar to wild-type
abnormal ectoplacental cone morphology ( J:115836 )
• abnormally shaped at E8.5
small ectoplacental cone ( J:115836 )
• reduced in size at E8.5
disorganized extraembryonic tissue ( J:115836 )
• highly disorganized; however overall morphology of the embryonic tissues is similar to wild-type

growth/size/body
embryonic growth retardation ( J:115836 )
• at E7.5
decreased embryo size ( J:115836 )
• at E7.5

cellular
decreased cell proliferation ( J:115836 )
• significant decrease in the number of mitotic cells at E7.5




Genotype
MGI:3696951
cn4
Allelic
Composition		 Atrxtm1Rjg/Atrx+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (78 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:115836 )
• fewer than expected found at E9.5; however, unlike hemizygous males some females do survive

reproductive system
abnormal reproductive system physiology ( J:115836 )
• some surviving females can reproduce

behavior/neurological
abnormal behavior ( J:115836 )
• surviving females display mild behavioral abnormalities

cellular
abnormal imprinting ( J:115836 )
• in surviving females expression of the paternal wild-type allele is seen in extraembryonic tissues; however, random X inactivation in the embryo is normal




Genotype
MGI:3056263
cn5
Allelic
Composition		 Etv6tm2Sho/Etv6tm2Sho
Tg(Gata1-cre)1Sho/?
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm2Sho mutation (0 available); any Etv6 mutation (144 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:93052 )
• megakaryocyte colony forming cells increased 5 fold
thrombocytopenia ( J:93052 )
• platelet count is reduced 50%

cellular
abnormal megakaryocyte differentiation ( J:93052 )
• megakaryocyte colony forming cells increased 5 fold




Genotype
MGI:3819386
cn6
Allelic
Composition		 Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Gata1-cre)1Sho/?
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcb1tm1Sho mutation (0 available); any Smarcb1 mutation (22 available)
Smarcb1tm3Sho mutation (1 available); any Smarcb1 mutation (22 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4356080
cn7
Allelic
Composition		 Etv6tm1(RUNX1)Haho/Etv6+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CD-1 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm1(RUNX1)Haho mutation (1 available); any Etv6 mutation (144 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:151639 )
• mice die postnatally due to severe submucosal lymphedema of the small intestine

immune system
immune system phenotype ( J:151639 )
N
• B cell development is normal with normal numbers of mature B cells
abnormal B cell differentiation ( J:151639 )
• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated
• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated
• however, fetal liver cell generated colonies are factor-dependent and not transformed
• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted

digestive/alimentary system
intestinal edema ( J:151639 )
• mice die postnatally due to severe submucosal lymphedema of the small intestine

growth/size/body
postnatal growth retardation ( J:151639 )
• mice fail to thrive

homeostasis/metabolism
intestinal edema ( J:151639 )
• mice die postnatally due to severe submucosal lymphedema of the small intestine

neoplasm
neoplasm ( J:151639 )
N
• mice do not develop tumors

embryo
embryo phenotype ( J:151639 )
N
• unlike in other mice lacking Etv6 expression, yolk vascular development is normal in mice that survive beyond E10.5

hematopoietic system
abnormal B cell differentiation ( J:151639 )
• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated
• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated
• however, fetal liver cell generated colonies are factor-dependent and not transformed
• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted




Genotype
MGI:5427349
cn8
Allelic
Composition		 Smarca1tm1Pick/Y
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca1tm1Pick mutation (0 available); any Smarca1 mutation (12 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:183998 )
• viable and fertile




Genotype
MGI:3814709
cn9
Allelic
Composition		 Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gata1-cre)1Sho mutation (2 available)
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (102 available)
Trpm7tm1Clph mutation (1 available); any Trpm7 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:140630 )
• no viable embryos were found, no time of lethality was provided




Genotype
MGI:3778208
cn10
Allelic
Composition		 Dkc1tm1Bsl/Y
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:80494 )
• no male embryos are recovered at E7.5 when the mutant allele is derived maternally
• same phenotype is observed when EIIa-cre transgenic males are used




Genotype
MGI:3778209
cn11
Allelic
Composition		 Dkc1tm2Bsl/Y
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm2Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:80494 )
• no male embryos are recovered at E7.5 when the floxed allele is derived from the mother
• same phenotype is observed when EIIa-cre transgenic males are used




Genotype
MGI:3778211
cn12
Allelic
Composition		 Dkc1tm2Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm2Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:80494 )
• no live embryos are recovered at E9.5 and most have been resorbed at E12.5, with inheritance of the maternally derived mutant allele
• same phenotype is observed when EIIa-cre transgenic males are used

embryo
increased trophectoderm apoptosis ( J:80494 )
• after E7.5, apoptotic nuclei are observed in the trophectoderm
abnormal embryo development ( J:80494 )
• at E8.5 and E9.5, embryos appear morphologically disorganized relative to wild-type
failure of initiation of embryo turning ( J:80494 )
• at E8.5 or E9.5, embryos do not show signs of axial rotation
embryonic growth arrest ( J:80494 )
• after E7.5, embryos become developmentally growth arrested
decreased embryo size ( J:80494 )
• at E8.5 and E9.5, embryos are visibly smaller than littermates
trophectoderm cell degeneration ( J:80494 )
• at E8.5 and E9.5, degeneration within the trophectoderm becomes more extensive

growth/size/body
decreased embryo size ( J:80494 )
• at E8.5 and E9.5, embryos are visibly smaller than littermates

reproductive system
transmission ratio distortion ( J:80494 )
• females with the deletion on the paternally-inherited allele are unable to transmit the deletion to offspring; only homozygous Dkc1+, cre transgene-negative male and female offspring are obtained when females heterozygous for the deleted allele are crossed to wild-type males

cellular
increased trophectoderm apoptosis ( J:80494 )
• after E7.5, apoptotic nuclei are observed in the trophectoderm




Genotype
MGI:3778210
cn13
Allelic
Composition		 Dkc1tm1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:80494 )
• no live embryos are recovered at E9.5 and most have been resorbed at E12.5, with inheritance of the maternally derived mutant allele
• same phenotype is observed when EIIa-cre transgenic males are used

embryo
increased trophectoderm apoptosis ( J:80494 )
• after E7.5, apoptotic nuclei are observed in the trophectoderm
abnormal embryo development ( J:80494 )
• at E8.5 and E9.5, embryos appear morphologically disorganized relative to wild-type
failure of initiation of embryo turning ( J:80494 )
• at E8.5 or E9.5, embryos do not show signs of axial rotation
embryonic growth arrest ( J:80494 )
• after E7.5, embryos become developmentally growth arrested
decreased embryo size ( J:80494 )
• at E8.5 and E9.5, embryos are visibly smaller than littermates
trophectoderm cell degeneration ( J:80494 )
• at E8.5 and E9.5, degeneration within the trophectoderm becomes more extensive

growth/size/body
decreased embryo size ( J:80494 )
• at E8.5 and E9.5, embryos are visibly smaller than littermates

reproductive system
transmission ratio distortion ( J:80494 )
• females with the deletion on the paternally-inherited allele are unable to transmit the deletion to offspring; only homozygous Dkc1+, cre transgene-negative male and female offspring are obtained when females heterozygous for the deleted allele are crossed to wild-type males

cellular
increased trophectoderm apoptosis ( J:80494 )
• after E7.5, apoptotic nuclei are observed in the trophectoderm




Genotype
MGI:3778213
cx14
Allelic
Composition		 Dkc1tm1.1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1.1Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:80494 )
• if the female embryos inherit the mutant allele paternally, development is normal; postnatally through adulthood (12 months), females display normal morphology, tissue histology and physiological parameters
• same phenotype is observed when EIIa-cre transgenic males are used




Genotype
MGI:3778212
cx15
Allelic
Composition		 Dkc1tm2.1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm2.1Bsl mutation (0 available); any Dkc1 mutation (2 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:80494 )
• if the female embryos inherit the mutant allele paternally, development is normal; postnatally through adulthood (12 months), females display normal morphology, tissue histology and physiological parameters




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Send questions and comments to User Support. 		last database update
11/12/2024
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