Phenotypes associated with this allele

• Allele Symbol: Nts^tm1Dob
• Allele Name: targeted mutation 1, Paul R Dobner
• Allele ID: MGI:2446607
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nts^tm1Dob/Nts^tm1Dob	involves: 129S4/SvJae * C57BL/6J	MGI:3041445

Genotype
MGI:3041445

hm1

• Allelic Composition: Nts^tm1Dob/Nts^tm1Dob
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:80590 )

• homozygous null mice displayed an altered response to the typical antipsychotic drug haloperidol: specifically, haloperidol induction of Fos was markedly attenuated in the dorsolateral and central caudate-putamen (but not the nucleus accumbens) of homozygous null mice

• compared with wild-type mice, homozygous null mice displayed no significant differences in either baseline catalepsy scores or in catalepsy measured 45 and 90 min after haloperidol challenge

• notably, homozygous null mice were indistinguishable from wild-type mice in appearance, body weight, gross anatomy, fertility, and behavior