Analysis Tools
nervous system
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• both slow and medium after hyperpolarization (AHP) responses are decreased compared to in wild-type mice (slow AHP, -0.97+/-0.13 mV compared to -0.3+/-0.05 mV in wild-type mice; medium AHP, -1.8+/-0.15 mV to -1.35+/-0.1 mV in wild-type mice)
• however, resting potentials, input resistances, and action potential thresholds and amplitudes are normal
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immune system
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• no mice develop scrapie for up to 400 days post-infection with no evidence of scrapie or accumulation of PrnpSc in one mouse that was culled due to intercurrent illness
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behavior/neurological
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• mice are indistinguishable from wild-type mice with normal gait, posture, motor control, coordination, autonomic function, general excitability and aggression at time points when cre is expressed, 3 to 5 months and 6 to 15 months
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