All Phenotypes St3gal4<tm1.1Jxm> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

thrombocytopenia ( J:136946 )

abnormal platelet physiology ( J:136946 )

• despite an accumulation of platelets in the liver, platelets fail to normally associate with Kupffer cells

homeostasis/metabolism

abnormal platelet physiology ( J:136946 )

• despite an accumulation of platelets in the liver, platelets fail to normally associate with Kupffer cells

increased bleeding time ( J:136946 )

immune system

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

abnormal response to infection ( J:136946 )

• following infection with S. pneumoniae, mice fail to exhibit normal thrombocytopenia and platelet half-life is not decreased as in similarly treated wild-type mice

cellular

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

Allelic Composition	St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:189086 )

N	• mice exhibit normal leukocytosis and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N	• mice exhibit normal leukocytosis and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

thrombocytopenia ( J:189086 )

increased mean platelet volume ( J:189086 )

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

Allelic Composition	Asgr1^tm1Sau/Asgr1^tm1Sau St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr1^tm1Sau mutation (1 available); any Asgr1 mutation (16 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136946 )

N	• unlike either single homozygote, mice exhibit normal bleed times

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

abnormal blood coagulation ( J:136946 )

• mice exhibit a longer bleed time compared to in Asgr1^tm1Sau homozygotes that is less than in St3gal4^tm1.1Jxm homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N	• mice exhibit normal numbers of red blood cells and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

thrombocytopenia ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

increased mean platelet volume ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24