All Phenotypes St3gal4<tm1.1Jxm> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

thrombocytopenia ( J:136946 )

abnormal platelet physiology ( J:136946 )

• despite an accumulation of platelets in the liver, platelets fail to normally associate with Kupffer cells

homeostasis/metabolism

abnormal platelet physiology ( J:136946 )

• despite an accumulation of platelets in the liver, platelets fail to normally associate with Kupffer cells

increased bleeding time ( J:136946 )

immune system

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

abnormal response to infection ( J:136946 )

• following infection with S. pneumoniae, mice fail to exhibit normal thrombocytopenia and platelet half-life is not decreased as in similarly treated wild-type mice

cellular

abnormal leukocyte tethering or rolling ( J:117085 )

• after exteriorization of the cremaster muscle, leukocyte rolling flux fraction (RFF), untreated mutants is significantly higher than in controls

• injection of P-selectin-blocking antibody into mutants completely abolishes rolling, while rolling is reduced in controls; this suggests that L-selectin-mediated rolling is absent in mutants

• treatment of mice with P- and E-selectin-blocking antibodies after TNFalpha intrascrotal injection dramatically reduces RFF (to <1%) compared to controls

Allelic Composition	St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:189086 )

N	• mice exhibit normal leukocytosis and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N	• mice exhibit normal leukocytosis and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

thrombocytopenia ( J:189086 )

increased mean platelet volume ( J:189086 )

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

Allelic Composition	Asgr1^tm1Sau/Asgr1^tm1Sau St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr1^tm1Sau mutation (1 available); any Asgr1 mutation (16 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136946 )

N	• unlike either single homozygote, mice exhibit normal bleed times

Allelic Composition	Asgr2^tm1Her/Asgr2^tm1Her St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr2^tm1Her mutation (2 available); any Asgr2 mutation (20 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

abnormal blood coagulation ( J:136946 )

• mice exhibit a longer bleed time compared to in Asgr1^tm1Sau homozygotes that is less than in St3gal4^tm1.1Jxm homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N	• mice exhibit normal numbers of red blood cells and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

thrombocytopenia ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

increased mean platelet volume ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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