All Phenotypes Tg(CMV-IghvaD11)CCat MGI Mouse

• mice appear normal but body weight is slightly decreased by 25% compared to littermates

• when given a new learning test following the retention test, mice show a deficit in transfer of learning capacity to a new situation compared to controls

abnormal long-term spatial reference memory ( J:79946 )

• when retested 31 days after initial training period, mice do not retain level of performance initial acquired with learning

abnormal spatial working memory ( J:79946 )

• in a radial maze test, mice show working memory errors

impaired coordination ( J:79946 )

• mice show marked impairment in coordination and fatigability assessed by the rotarod test

abnormal limb posture ( J:79946 )

• adult mice show abnormal hind limb position when walking or suspended by tail

abnormal gait ( J:79946 )

• adults display waddling gait due to abnormal hind limb position; mice walk on tiptoes of hind feet

increased thermal nociceptive threshold ( J:79946 )

• adult transgenic mice show increased latency in hot plate test

increased neuron apoptosis ( J:79946 )

• majority of neurons in lumbar DRG have pyknotic nuclei

abnormal sympathetic system morphology ( J:79946 )

• innervating fibers in the spleen are scattered throughout germinal center and marginal zone, without reaching the central artery

abnormal superior cervical ganglion morphology ( J:79946 )

• cells are greatly reduced in size (157-193 um² vs 218-311 um² in controls) at 2 months

small superior cervical ganglion ( J:79946 )

• markedly smaller at 2 months of age compared to controls

abnormal hippocampal mossy fiber morphology ( J:79946 )

• extent of CA3 mossy fibers is markedly reduced at 2 months

abnormal cholinergic neuron morphology ( J:79946 )

• number of choline acetyl transferase ChAT neurons in basal forebrain and hippocampus is reduced in adult animals relative to controls

• cell bodies of ChAT-positive fibers projecting to cortex and hippocampus show marked shrinkage

abnormal lumbar dorsal root ganglion morphology ( J:79946 )

• neuron size with respect to cell body size is dramatically reduced with median size of 425 um² in controls vs 75 um² in transgenic mice at 2 months

abnormal skeletal muscle fiber morphology ( J:79946 )

• fibers show an irregular shape

decreased skeletal muscle fiber diameter ( J:79946 )

• fibers show a decreased cross-sectional area

decreased skeletal muscle mass ( J:79946 )

• at 2 months, significant reduction of the mass (atrophy) of longitudinal dorsal muscles and the flexor and abducent muscles of the hind limbs is observed in adults, but not in mice 2-30 days postnatal

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

abnormal splenic cell ratio ( J:79946 )

• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

abnormal splenic cell ratio ( J:79946 )

• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased

scoliosis ( J:79946 )

• mice often develop scoliosis of the back

increased neuron apoptosis ( J:79946 )

• majority of neurons in lumbar DRG have pyknotic nuclei

increased splenocyte apoptosis ( J:79946 )

• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls

amyloidosis ( J:79946 )

• amyloid deposits are seen in sarcoplasm of skeletal muscle

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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