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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tTA)1Pjln
transgene insertion 1, Peter J Nielsen
MGI:2447131
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pou2af1tm1Pjln/Pou2af1tm1Pjln
Tg(tetO-Pou2af1)1Pjln/0
Tg(tTA)1Pjln/0 		involves: C57BL/6 MGI:4354504


Genotype
MGI:4354504
cx1
Allelic
Composition		 Pou2af1tm1Pjln/Pou2af1tm1Pjln
Tg(tetO-Pou2af1)1Pjln/0
Tg(tTA)1Pjln/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2af1tm1Pjln mutation (0 available); any Pou2af1 mutation (15 available)
Tg(tetO-Pou2af1)1Pjln mutation (0 available)
Tg(tTA)1Pjln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:67362 )
N
• unlike in Pou2af1tm1Pjln homozygotes, mice exhibit normal numbers of pro-, pre-, immature, and transitional immature B cells and normal rates of B cell apoptosis
decreased B cell number ( J:67362 )
• in the spleen
decreased immunoglobulin level ( J:67362 )
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice

hematopoietic system
decreased B cell number ( J:67362 )
• in the spleen
decreased immunoglobulin level ( J:67362 )
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory