Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Prnp)a20Cwe transgene insertion a20, Charles Weissmann MGI:2447133 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice
• however, accumulation of prions in medial lymph nodes is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in culture
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• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells
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• in culture
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• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers
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• gammadelta T cell differentiation is promoted while alphabeta T cell differentiation is impaired compared to in wild-type mice
• T cell differentiation is partially arrested at DN3 unlike in wild-type mice
• however, supplementation with copper partially reverses defects in T cell differentiation
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• partially reversed by copper supplementation
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• partially reversed by copper supplementation
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• slightly
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• 9-fold, partially reversed by copper supplementation
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• the proportion of CD19+ and B220+ B cells is increased compared to in wild-type mice
• however, the total number of B cells is normal
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• copper levels in the brain and thymus are increased compared to in wild-type mice
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• after 12 months, mice exhibit increased brain copper levels compared with wild-type mice
• copper levels in the synaptosomes are increased compared to in wild-type mice
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• mice exhibit an increase in brain magnesium level compared with wild-type mice
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• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers
|
|
• gammadelta T cell differentiation is promoted while alphabeta T cell differentiation is impaired compared to in wild-type mice
• T cell differentiation is partially arrested at DN3 unlike in wild-type mice
• however, supplementation with copper partially reverses defects in T cell differentiation
|
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• partially reversed by copper supplementation
|
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• partially reversed by copper supplementation
|
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• slightly
|
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• 9-fold, partially reversed by copper supplementation
|
|
• the proportion of CD19+ and B220+ B cells is increased compared to in wild-type mice
• however, the total number of B cells is normal
|
|
• after 12 months, mice exhibit increased brain copper levels compared with wild-type mice
• copper levels in the synaptosomes are increased compared to in wild-type mice
|
|
• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• scrapie-innoculated transgenic mice displayed typical scrapie symptoms, such as hind limb paresis, foot clasp reflex, kyphosis, ataxia, disorientation and minced gait
• incubation times to occurrence of first symptoms as well as the terminal state were shorter than wild-type control group
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following inoculation with RML scrapie prion, mice exhibit more rapid scrapie development and spread with axonal degeneration compared with similarly treated wild-type mice
(J:130657)
• mice inoculated with mouse-adapted Rocky Mountain Laboratory prions develop scrapie after 74 +/- 6 days compared to wild-type mice that develop scrapie after 170 +/- 12 days
(J:143528)
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• following inoculation with RML scrapie prion
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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