All Phenotypes Tg(Prnp)c35Cwe MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Prnp)c35Cwe
transgene insertion c35, Charles Weissmann
MGI:2447134

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prnp^tm1Cwe/Prnp^tm1Cwe Tg(Prnp)c35Cwe/0	Not Specified	MGI:3531093

Allelic Composition	Prnp^tm1Cwe/Prnp^tm1Cwe Tg(Prnp)c35Cwe/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm1Cwe mutation (43 available); any Prnp mutation (148 available)
Tg(Prnp)c35Cwe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hindlimb paralysis ( J:32214 )

• in some cases, mice not innoculated for scrapie developed paralysis of the hindlimbs as early as 4-6 months after birth

immune system

increased susceptibility to prion infection ( J:32214 )

• scrapie-innoculated transgenic mice displayed typical scrapie symptoms, such as hind limb paresis, foot clasp reflex, kyphosis, ataxia, disorientation and minced gait

• incubation times to occurrence of first symptoms as well as the terminal state were shorter than wild-type control group

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24