All Phenotypes Tg(Prnp)c35Cwe MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Prnp)c35Cwe
transgene insertion c35, Charles Weissmann
MGI:2447134

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prnp^tm1Cwe/Prnp^tm1Cwe Tg(Prnp)c35Cwe/0	Not Specified	MGI:3531093

Allelic Composition	Prnp^tm1Cwe/Prnp^tm1Cwe Tg(Prnp)c35Cwe/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^tm1Cwe mutation (37 available); any Prnp mutation (142 available)
Tg(Prnp)c35Cwe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hindlimb paralysis ( J:32214 )

• in some cases, mice not innoculated for scrapie developed paralysis of the hindlimbs as early as 4-6 months after birth

immune system

increased susceptibility to prion infection ( J:32214 )

• scrapie-innoculated transgenic mice displayed typical scrapie symptoms, such as hind limb paresis, foot clasp reflex, kyphosis, ataxia, disorientation and minced gait

• incubation times to occurrence of first symptoms as well as the terminal state were shorter than wild-type control group

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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