Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp)2D1Lnq
• Allele Name: transgene insertion 2D1, Susan Lindquist
• Allele ID: MGI:2447138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp)2D1Lnq/0	Not Specified	MGI:2653416

Genotype
MGI:2653416

tg1

• Allelic Composition: Tg(Prnp)2D1Lnq/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:80582 )

• progeny from the founder were euthanized at 10-11 weeks of age when death was obviously imminent

nervous system

abnormal nervous system morphology ( J:80582 )

• the founder mouse displays no phenotype but all progeny from this founder develop the phenotypes below

cerebellum atrophy ( J:80582 )

• cerebellar atrophy is seen at 7 weeks of age

gliosis ( J:80582 )

• severe gliosis

neuron degeneration ( J:80582 )

• massive neuronal loss in the cerebellar granular layer and the molecular layer, however Purkinje neurons are not affected, after 3 weeks of age

growth/size/body

postnatal growth retardation ( J:80582 )

• grow more slowly than wild-type after 29 days of ag

behavior/neurological

ataxia ( J:80582 )

• mice develop severe ataxia at 4 weeks of age

abnormal tail movements ( J:80582 )

• at 7 weeks of age, mutants exhibit tail rigidity

abnormal gait ( J:80582 )

• unsteady gait at 29 days of age