All Phenotypes Tg(Prnp)1D4Lnq MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Prnp)1D4Lnq
transgene insertion 1D4, Susan Lindquist
MGI:2447139

Summary

2 genotypes

Allelic Composition	Tg(Prnp)1D4Lnq/Tg(Prnp)1D4Lnq
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

cerebellum atrophy ( J:80582 )

• cerebellar atrophy

gliosis ( J:80582 )

neuron degeneration ( J:80582 )

• develop pathology with much faster onset of about 2 months compared to hemizygous transgenic mice

behavior/neurological

ataxia ( J:80582 )

Allelic Composition	Tg(Prnp)1D4Lnq/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:80582 )

• frequent scratching at 5-12 months of age

ataxia ( J:80582 )

• mild ataxia after 12 months of age

growth/size/body

weight loss ( J:80582 )

• weight loss several weeks after one year of age

nervous system

abnormal cerebellum morphology ( J:80582 )

gliosis ( J:80582 )

• severe gliosis

neuron degeneration ( J:80582 )

• massive neuronal loss in the cerebellar granular layer and the molecular layer, however Purkinje neurons are not affected

integument

disheveled coat ( J:80582 )

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