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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(THY1-APP)2Somm
transgene insertion 2, Bernd Sommer
MGI:2447145
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(THY1-APP)2Somm/0 involves: C57BL/6J * DBA/2 MGI:2652461


Genotype
MGI:2652461
tg1
Allelic
Composition
Tg(THY1-APP)2Somm/0
Genetic
Background
involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develop amyloid beta deposits (plaques) in the neocortex and hippocampus by 18 months of age
• majority of deposits are of the diffuse type with a few congophilic plaques
• mutants exhibit inflammatory responses in the brain, showing a glial response

immune system
• mutants exhibit inflammatory responses in the brain, showing a glial response

homeostasis/metabolism
• develop amyloid beta deposits (plaques) in the neocortex and hippocampus by 18 months of age
• majority of deposits are of the diffuse type with a few congophilic plaques





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory