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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptdss2Gt(KST314)Byg
gene trap KST314, BayGenomics
MGI:2447151
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:2653458
cx2
 		Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803015
cx3
 		Ptdss1tm1Jev/Ptdss1+
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803016
cx4
 		Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2+ 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803017


Genotype
MGI:2653458
hm1
Allelic
Composition		 Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased Leydig cell number ( J:80673 )
• in atrophic testes
decreased testis weight ( J:80673 )
• a 13% reduction in testis weight for about 90% of male mice
testicular atrophy ( J:80673 )
• testes about 30% of normal size in 3 out of 25 male

homeostasis/metabolism
increased circulating follicle stimulating hormone level ( J:80673 )
• increased levels in males possibly due to subtle Sertioli cell dysfunction

reproductive system
increased Leydig cell number ( J:80673 )
• in atrophic testes
decreased testis weight ( J:80673 )
• a 13% reduction in testis weight for about 90% of male mice
testicular atrophy ( J:80673 )
• testes about 30% of normal size in 3 out of 25 male
male infertility ( J:80673 )
• although all females and most males were fertile, about 10% of males were infertile or subfertile




Genotype
MGI:3803015
cx2
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3803016
cx3
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1+
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137106 )
N
• despite reduction in phosphatidylserine levels, mice exhibit a normal lifespan

homeostasis/metabolism
abnormal phospholipid level ( J:137106 )
• phospatidylserine levels are reduced by 23% in brain, by 29% in liver, and by 25% in heart compared to in wild-type mice




Genotype
MGI:3803017
cx4
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137106 )
N
• despite reduction in phosphatidylserine levels, mice exhibit a normal lifespan

homeostasis/metabolism
abnormal phospholipid level ( J:137106 )
• phospatidylserine levels are reduced by 40% in brain, by 29% in liver, and by 33% in heart compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory