All Phenotypes Lcp2<tm1Geha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lcp2^tm1Geha
targeted mutation 1, Raif S Geha
MGI:2447170

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lcp2^tm1Geha/Lcp2^tm1Geha	involves: 129S4/SvJae	MGI:3777290
cx2	Clnk^tm1Rygo/Clnk^tm1Rygo Lcp2^tm1Geha/Lcp2^tm1Geha	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c	MGI:3777289

Allelic Composition	Lcp2^tm1Geha/Lcp2^tm1Geha
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2^tm1Geha mutation (0 available); any Lcp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased NK cell number ( J:131621 )

impaired natural killer cell mediated cytotoxicity ( J:131621 )

• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells

decreased interferon-gamma secretion ( J:131621 )

• following alpha-GalCer-stimulated or co-culture with YAC-1 cells, IFN-gamma secretion from spleen natural killer T cells is absent

hematopoietic system

increased NK cell number ( J:131621 )

impaired natural killer cell mediated cytotoxicity ( J:131621 )

• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells

Allelic Composition	Clnk^tm1Rygo/Clnk^tm1Rygo Lcp2^tm1Geha/Lcp2^tm1Geha
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnk^tm1Rygo mutation (2 available); any Clnk mutation (31 available)
Lcp2^tm1Geha mutation (0 available); any Lcp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased NK cell number ( J:131621 )

impaired natural killer cell mediated cytotoxicity ( J:131621 )

• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells

decreased interferon-gamma secretion ( J:131621 )

• alpha-GalCer-stimulated IFN-gamma secretion form spleen natural killer T cells is absent despite the presence of the cells

• however, natural killer cells co-cultured with YAC-1 cells produce normal levels of IFN-gamma

hematopoietic system

increased NK cell number ( J:131621 )

impaired natural killer cell mediated cytotoxicity ( J:131621 )

• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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