Phenotypes associated with this allele

• Allele Symbol: Snai2^tm1Look
• Allele Name: targeted mutation 1, A Thomas Look
• Allele ID: MGI:2447174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snai2^tm1Look/Snai2^tm1Look	involves: 129X1/SvJ * C57BL/6	MGI:2653374

Genotype
MGI:2653374

hm1

• Allelic Composition: Snai2^tm1Look/Snai2^tm1Look
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:80652 )

• mice exposed to semi-lethal doses of gamma-irradiation die more quickly and in greater numbers than controls; gastrointestinal mucosa appear normal in moribund mice; authors suggest premature lethality is due to damage to bone marrow progenitor cells

growth/size/body

postnatal growth retardation ( J:80652 )

• evident after birth

hematopoietic system

hematopoietic system phenotype ( J:80652 )

N • circulating blood cell counts were similar to controls

abnormal hematopoietic system morphology/development ( J:80652 )

• number of hematopoietic colony-forming progenitors were increased compared to control values; these cells appeared to be more sensitive to radiation-induced apoptosis than controls

immune system

immune system phenotype ( J:80652 )

N • the numbers of B and T cells, the mitogenic responses of splenic and thymic lymphocytes and the serum levels of the immunoglobulins were similar to controls

blepharitis ( J:80652 )

• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

vision/eye

blepharitis ( J:80652 )

• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:80652 )

• mice exposed to semi-lethal doses of gamma-irradiation die more quickly and in greater numbers than controls; gastrointestinal mucosa appear normal in moribund mice; authors suggest premature lethality is due to damage to bone marrow progenitor cells