Phenotypes associated with this allele

• Allele Symbol: Snai2^tm1Grid
• Allele Name: targeted mutation 1, Tom Gridley
• Allele ID: MGI:2447175
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snai2^tm1Grid/Snai2^tm1Grid	involves: 129S1/Sv	MGI:2652595
hm2	Snai2^tm1Grid/Snai2^tm1Grid	involves: 129S1/Sv * C57BL/6J	MGI:5649252

Genotype
MGI:2652595

hm1

• Allelic Composition: Snai2^tm1Grid/Snai2^tm1Grid
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:48521 )

• animals are significantly smaller than littermates

Genotype
MGI:5649252

hm2

• Allelic Composition: Snai2^tm1Grid/Snai2^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6J

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:139512 )

• at E9.5 cardiac cushions have significantly fewer mesenchymal cells

• in atrioventricular canal explants from E9.5 mice cells that do migrate have a rounded morphology and are not able to differentiate into spindled mesenchymal cells

abnormal fetal atrioventricular canal morphology ( J:139512 )

• atrioventricular canal explants from E9.5 mice have significantly reduced migration and invasion compared to heterozygous controls

• at E10.5 there is an increase in proliferation of both endocardial and mesenchymal cells in the AV canal

decreased atrioventricular cushion size ( J:139512 )

• at E9.5 cardiac cushions have significantly fewer mesenchymal cells

• however, by E10.5 cellularity of cardiac cushions is comparable to wild-type controls