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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Papolbtm1Tba
targeted mutation 1, Tadashi Baba
MGI:2447177
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Papolbtm1Tba/Papolbtm1Tba involves: 129S2/SvPas * C57BL/6 MGI:2652551


Genotype
MGI:2652551
hm1
Allelic
Composition		 Papolbtm1Tba/Papolbtm1Tba
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Papolbtm1Tba mutation (1 available); any Papolb mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:80657 )
• increased apoptosis of germ cells
small seminiferous tubules ( J:80657 )
• 15%-20% reduction in diameter of seminiferous tubules
decreased testis weight ( J:80657 )
• 45% reduction in testicular weight
arrest of spermatogenesis ( J:80657 )
• spermatids develop until step 7

endocrine/exocrine glands
small seminiferous tubules ( J:80657 )
• 15%-20% reduction in diameter of seminiferous tubules
decreased testis weight ( J:80657 )
• 45% reduction in testicular weight

cellular
increased male germ cell apoptosis ( J:80657 )
• increased apoptosis of germ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory