Analysis Tools
mortality/aging
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• intravenous infection with encapsulated S. aureus, Reynolds strain, results in 20% death by 6-8 days compared to 0% death in similarly infected wild-type mice
• 50% of mice infected intravenously with unencapsulated S. aureus, strain 3825-4, succumb to infection compared to 0% death in similarly infected wild-type mice
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immune system
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• show a 40-50% reduction in phagocytosis of S.aureus
• comparable levels of internalization of E. coli relative to wild-type
• 60% reduction in the ability to internalize lipoteichoic acid
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• macrophages treated with S. aureus for 4 hours show a 65-75% decrease in IL-12 secretion as compared with wild-type macrophage
• macrophages treated with lipoteichoic acid demonstrate a 60-70% decrease in IL-12 secretion
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• macrophages treated with E.coli show a 25% decrease in the secretion of IL-6
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• macrophages treated with S. aureus for 4 hours show a 65-75% decrease in TNF alpha secretion as compared with wild-type macrophage
• macrophages treated with lipoteichoic acid demonstrate a 60-70% defect in TNF secretion
• macrophages treated with E.coli show a 25% decrease in the secretion of TNF alpha
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• pericardial and perinephric abscess formation in mice infected intravenously with unencapsulated S. aureus
• perinephric abscess formation in 50% of mice infected intravenously with encapsulated S.aureus
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• intravenous infection with encapsulated S. aureus, Reynolds strain, results in 20% death by 6-8 days compared to 0% death in similarly infected wild-type mice
• 50% of mice infected intravenously with unencapsulated S. aureus, strain 3825-4, succumb to infection compared to 0% death in similarly infected wild-type mice
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• mice infected with encapsulated S. aureus, Reynolds strain, develop bacteraemia, resulting in a 3.8 x 10^9 S. aureus colony forming units per milliliter of blood on day
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cardiovascular system
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• 100% of the surviving mice infected intravenously with unencapsulated S. aureus strain 3825-4, develop perinephric and/or pericardial abscesses
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renal/urinary system
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• 50% of the animals infected intravenously with encapsulated S. aureus, Reynolds strain, have perinephric abscess formation whereas only 1 of 10 wild-type mice have an apparent abscess of the kidney
• 100% of the surviving mice infected intravenously with unencapsulated S. aureus strain 3825-4, develop perinephric and/or pericardial abscesses
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hematopoietic system
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• show a 40-50% reduction in phagocytosis of S.aureus
• comparable levels of internalization of E. coli relative to wild-type
• 60% reduction in the ability to internalize lipoteichoic acid
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cellular
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• show a 40-50% reduction in phagocytosis of S.aureus
• comparable levels of internalization of E. coli relative to wild-type
• 60% reduction in the ability to internalize lipoteichoic acid
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