Phenotypes associated with this allele

• Allele Symbol: Smad4^m4Mag
• Allele Name: mutation 4, Terry Magnuson
• Allele ID: MGI:2447208
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad4^m4Mag/Smad4^m4Mag	either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)	MGI:3713872
ht2	Smad4^m4Mag/Smad4^+	involves: 129S/Sv * Black Swiss * C57BL/6	MGI:3701498
ht3	Smad4^m4Mag/Smad4^tm1Cxd	either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)	MGI:3713871

Genotype
MGI:3713872

hm1

• Allelic Composition: Smad4^m4Mag/Smad4^m4Mag
• Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:80520 )

• embryos do not survive embryogenesis, and display defects not compatible with life around ~E7.5

embryo

failure to gastrulate ( J:80520 )

embryonic growth retardation ( J:80520 )

• at E7.5, animals are severely growth retarded

absent mesoderm ( J:80520 )

• embryos do not form mesoderm due to failure of gastrulation

growth/size/body

embryonic growth retardation ( J:80520 )

• at E7.5, animals are severely growth retarded

Genotype
MGI:3701498

ht2

• Allelic Composition: Smad4^m4Mag/Smad4⁺
• Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6

neoplasm

increased tumor incidence ( J:106440 )

increased stomach tumor incidence ( J:106440 )

increased ovary tumor incidence ( J:106440 )

♀

increased lung tumor incidence ( J:106440 )

digestive/alimentary system

abnormal large intestine morphology ( J:106440 )

abnormal cecum morphology ( J:106440 )

abnormal small intestine morphology ( J:106440 )

abnormal duodenum morphology ( J:106440 )

abnormal stomach glandular epithelium morphology ( J:106440 )

disorganized stomach mucosa ( J:106440 )

• stomachs of 11 month old mice, in section, appear disorganized and hyperplastic

gastric polyps ( J:106440 )

• 90% of mice form polyps by 18 months of age

• stomachs of 11 month old mice may appear distended even when empty because the entire stomach comprises hyperproliferated tissue

• polyp structure is indicative of an adenocarcinoma

• lymphocyte infiltration is frequently seen

• varying sized polyps cover the mucosa by 11 months of age

• by 18 months of age 92% of mice have gastric polyps compared with 2% in wild-type siblings

increased stomach tumor incidence ( J:106440 )

endocrine/exocrine glands

increased ovary tumor incidence ( J:106440 )

♀

respiratory system

increased lung tumor incidence ( J:106440 )

reproductive system

increased ovary tumor incidence ( J:106440 )

♀

Genotype
MGI:3713871

ht3

• Allelic Composition: Smad4^m4Mag/Smad4^tm1Cxd
• Genetic Background: either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:80520 )

• embryos do not survive embryogenesis, and display defects not compatible with life aound ~E7.5

embryo

failure to gastrulate ( J:80520 )

embryonic growth retardation ( J:80520 )

• at E7.5, animals are severely growth retarded

absent mesoderm ( J:80520 )

• embryos do not form mesoderm due to failure of gastrulation

growth/size/body

embryonic growth retardation ( J:80520 )

• at E7.5, animals are severely growth retarded