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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(RIP1-Tag)5Dh
transgene insertion 5, Douglas Hanahan
MGI:2447333
Summary 3 genotypes


Genotype
MGI:3809714
cx1
Allelic
Composition		 Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Tg(RIP1-Tag)5Dh/0
Genetic
Background		 C3.Cg-Rgs5tm1.1Rgan Tg(RIP1-Tag)5Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs5tm1.1Rgan mutation (0 available); any Rgs5 mutation (21 available)
Tg(RIP1-Tag)5Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased insulinoma incidence ( J:136259 )
• mice exhibit increased tumor growth with increased tumor burden and premature death due to hypoglycemia compared to wild-type mice
• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice

mortality/aging
premature death ( J:136259 )
• mice exhibit premature death due to hypoglycemia
• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice

neoplasm
increased insulinoma incidence ( J:136259 )
• mice exhibit increased tumor growth with increased tumor burden and premature death due to hypoglycemia compared to wild-type mice
• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice
abnormal tumor morphology ( J:136259 )
• tumor vasculature is normalized unlike in Tg(RIP1-Tag)5Dh mice with fewer enlarged vessels
• tumors exhibit more mature pericytes, increased oxygen supply and 50% reduced permeability compared to in Tg(RIP1-Tag)5Dh mice
• in adoptive transfer experiments, tumors exhibit an increase in spontaneous T cell infiltrate compared to in Tg(RIP1-Tag)5Dh mice
• T cell infiltrate into tumors is increased following vaccination unlike in Tg(RIP1-Tag)5Dh mice
• AG104A fibrosarcomas transferred into mice exhibit increased growth, increased vasculature, decreased vessel permeability and reduced hypoxia compared to tumors transferred into Tg(RIP1-Tag)5Dh mice
increased tumor growth/size ( J:136259 )
• AG104A fibrosarcomas transferred into mice exhibit increased growth compared to tumors transferred into Tg(RIP1-Tag)5Dh mice
preneoplasia ( J:136259 )
• mice exhibit early tumorigenesis with comparable numbers of angiogenic islets per mouse as in Tg(RIP1-Tag)5Dh mice

homeostasis/metabolism
hypoglycemia ( J:136259 )
• mice exhibit premature death due to hypoglycemia
edema ( J:136259 )
• following cerebral ischemia, mice exhibit reduced edema compared to in Tg(RIP1-Tag)5Dh mice




Genotype
MGI:3809715
tg2
Allelic
Composition		 Tg(RIP1-Tag)5Dh/0
Genetic
Background		 C3.Cg-Rgs5tm1.1Rgan Tg(RIP1-Tag)5Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RIP1-Tag)5Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136259 )
• mice exhibit premature death due to hypoglycemia

neoplasm
increased insulinoma incidence ( J:136259 )
• mice exhibit tumor growth with tumor burden and premature death due to hypoglycemia unlike in wild-type mice
preneoplasia ( J:136259 )
• mice exhibit early tumorigenesis with comparable numbers of angiogenic islets per mouse as in Rgs5tm1.1Rgan/Rgs5tm1.1Rgan Tg(RIP1-Tag)5Dh mice

homeostasis/metabolism
hypoglycemia ( J:136259 )
• mice exhibit premature death due to hypoglycemia

endocrine/exocrine glands
increased insulinoma incidence ( J:136259 )
• mice exhibit tumor growth with tumor burden and premature death due to hypoglycemia unlike in wild-type mice




Genotype
MGI:3757563
tg3
Allelic
Composition		 Tg(RIP1-Tag)5Dh/?
Genetic
Background		 C3HeB/FeJ-Tg(RIP1-Tag)5Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RIP1-Tag)5Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:80168 )
• up to 60% of islets show infiltration, accompanied by beta cell destruction
increased insulinoma incidence ( J:80168 )
• transgenic mice develop pancreatic beta cell tumors
pancreas inflammation ( J:80168 )
• lymphocytic infiltration of islets is detected by 14-15 weeks of age; infiltrates consist of CD4+ T cells , B cells and macrophages
• small mononuclear cells are detected adhering to walls of high endothelial venule-like vessels in areas of infiltration

immune system
pancreas inflammation ( J:80168 )
• lymphocytic infiltration of islets is detected by 14-15 weeks of age; infiltrates consist of CD4+ T cells , B cells and macrophages
• small mononuclear cells are detected adhering to walls of high endothelial venule-like vessels in areas of infiltration

neoplasm
increased insulinoma incidence ( J:80168 )
• transgenic mice develop pancreatic beta cell tumors




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory