All Phenotypes Tg(APP695)3Dbo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(APP695)3Dbo
transgene insertion 3, David R Borchelt
MGI:2447334

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrp1^tm2Her/Lrp1^tm2Her Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0 Tg(Tagln-cre)1Her/0	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL	MGI:5471581
cx2	Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0	B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo	MGI:3718026
cx3	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax	MGI:4437308
cx4	Tlr2^tm1Kir/Tlr2^tm1Kir Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/?	involves: 129 * C3H/HeJ * C57BL/6	MGI:5428447
cx5	Sorl1^tm1Tew/Sorl1^tm1Tew Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	involves: 129 * C3H/HeJ * C57BL/6	MGI:5050413
cx6	Klc1^tm1Gsn/Klc1⁺ Tg(APP695)3Dbo/?	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6	MGI:3582996
cx7	Bace1^tm1Pcw/Bace1^tm1Pcw Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J	MGI:3720944
cx8	Bace1^tm1Pcw/Bace1⁺ Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J	MGI:3720945
cx9	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J	MGI:3720946
cx10	Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0	involves: C3H/HeJ * C57BL/6J	MGI:3663620
cx11	Tg(APP695)3Dbo/0 Tg(Eno2-PTGS2)32Pasi/0 Tg(PSEN1)5Dbo/0	involves: C3H/HeJ * C57BL/6J	MGI:3720017
cx12	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	involves: C3H/HeJ * C57BL/6J	MGI:3639713
cx13	Tg(APP695)3Dbo/0 Tg(PSEN1)S8-4Dbo/0	involves: C57BL/6J * C3H/HeJ	MGI:3663623
cx14	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0	Not Specified	MGI:3837363
tg15	Tg(APP695)3Dbo/0	B6.C3-Tg(APP695)3Dbo	MGI:3696575
tg16	Tg(APP695)3Dbo/0	involves: C3H/HeJ * C57BL/6J	MGI:3663621

Allelic Composition	Lrp1^tm2Her/Lrp1^tm2Her Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0 Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1^tm2Her mutation (0 available); any Lrp1 mutation (211 available)
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1)5Dbo mutation (1 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:192453 )

• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age

• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy

• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months

• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance

cerebral amyloid angiopathy ( J:192453 )

• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy

astrocytosis ( J:192453 )

• activation of astrocytes is enhanced compared to controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 1 year of age

homeostasis/metabolism

amyloid beta deposits ( J:192453 )

• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age

• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy

• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months

cerebral amyloid angiopathy ( J:192453 )

• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:192453
cerebral amyloid angiopathy	DOID:9246		J:192453

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0
Genetic Background	B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1)5Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:100956 )

• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females

behavior/neurological

impaired passive avoidance behavior ( J:142183 )

• poor retention latency exhibited in light-dark step through box

abnormal discrimination learning ( J:142183 )

• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls

• required higher trials to reach criterion and committed more errors in comparison to controls

behavioral despair ( J:142183 )

• increased duration of immobility in Porsolt forced swim test

abnormal touch/ nociception ( J:142183 )

• increased irritability in response to touch escape test as compared to control

abnormal nest building behavior ( J:142183 )

• poor nest building ability in comparison to controls

homeostasis/metabolism

amyloid beta deposits ( J:100956 )

• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:157228 )

homeostasis/metabolism

amyloid beta deposits ( J:157228 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:157228

Allelic Composition	Tlr2^tm1Kir/Tlr2^tm1Kir Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/?
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1)5Dbo mutation (1 available)
Tlr2^tm1Kir mutation (2 available); any Tlr2 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired passive avoidance behavior ( J:136387 )

• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber

abnormal long-term spatial reference memory ( J:136387 )

• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone

• acquisition of spatial memory in T-water maze tests is normal

nervous system

amyloid beta deposits ( J:136387 )

• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months

• higher brain levels of Abeta1-42

homeostasis/metabolism

amyloid beta deposits ( J:136387 )

• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months

• higher brain levels of Abeta1-42

Allelic Composition	Sorl1^tm1Tew/Sorl1^tm1Tew Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1^tm1Tew mutation (0 available); any Sorl1 mutation (132 available)
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:142501 )

• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta

• some of the largest differences in amyloid measures are detected in the cerebellum

homeostasis/metabolism

amyloid beta deposits ( J:142501 )

• some of the largest differences in amyloid measures are detected in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:142501

Allelic Composition	Klc1^tm1Gsn/Klc1⁺ Tg(APP695)3Dbo/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1^tm1Gsn mutation (1 available); any Klc1 mutation (54 available)
Tg(APP695)3Dbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:96346 )

• levels of amyloid beta are consistently elevated relative to controls

abnormal axon morphology ( J:96346 )

• increased axonal swelling independent of amyloid deposition

homeostasis/metabolism

amyloid beta deposits ( J:96346 )

• levels of amyloid beta are consistently elevated relative to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:96346

Allelic Composition	Bace1^tm1Pcw/Bace1^tm1Pcw Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1^tm1Pcw mutation (1 available); any Bace1 mutation (30 available)
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:123534 )

N	• mice perform as well as control mice in platform and probe trials in Morris water maze tasks

decreased anxiety-related response ( J:123534 )

• in open field test, mice are similar to Bace1^tm1Pcw homozygotes, and spend more time in open area at center of field than at periphery

abnormal locomotor activation ( J:123534 )

• swim speed is lower than other genotypes and nontransgenic mice in hidden and visible platform trials

nervous system

nervous system phenotype ( J:123534 )

N	• in 12- or 20-month old mice, no amyloid beta (Abeta) aggregation is detected in brains; no amyloid deposits are found

Allelic Composition	Bace1^tm1Pcw/Bace1⁺ Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:123534 )

abnormal spatial reference memory ( J:123534 )

• mice are significantly impaired in Morris water maze tasks

nervous system

amyloid beta deposits ( J:123534 )

• high level of amyloid beta aggregates are found in brain at 12 months of age

homeostasis/metabolism

amyloidosis ( J:123534 )

• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months

• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months

amyloid beta deposits ( J:123534 )

• high level of amyloid beta aggregates are found in brain at 12 months of age

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:123534 )

abnormal spatial learning ( J:123534 )

• mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field

abnormal spatial reference memory ( J:123534 )

• 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls

nervous system

amyloid beta deposits ( J:123534 )

• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

homeostasis/metabolism

amyloidosis ( J:123534 )

• mice display amyloid beta aggregates at 12 and 20 months

amyloid beta deposits ( J:123534 )

• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:123534
Alzheimer's disease 3	DOID:0110042	OMIM:607822	J:123534

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1)5Dbo/0
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1)5Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:100961 )

N	• no differences in neuron number in cingulate cortex relative to wild-type

amyloid beta deposits ( J:43788 , J:87691 , J:100961 )

• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)

• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)

• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)

• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)

astrocytosis ( J:43788 )

• associated with dystropic neuritis in cortex and hippocampus

abnormal neuron morphology ( J:43788 )

• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus

abnormal neuron physiology ( J:100961 )

• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons

homeostasis/metabolism

amyloid beta deposits ( J:43788 , J:87691 , J:100961 )

• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)

• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)

• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)

• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:43788
Alzheimer's disease 3	DOID:0110042	OMIM:607822	J:43788
Alzheimer's disease 4	DOID:0110040	OMIM:606889	J:43788

Allelic Composition	Tg(APP695)3Dbo/0 Tg(Eno2-PTGS2)32Pasi/0 Tg(PSEN1)5Dbo/0
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(Eno2-PTGS2)32Pasi mutation (0 available)
Tg(PSEN1)5Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:100961 )

N	• no differences in neuron number in cingulate cortex relative to wild-type

amyloid beta deposits ( J:100961 )

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation

homeostasis/metabolism

amyloid beta deposits ( J:100961 )

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:87691 , J:104236 )

• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)

• 150% increase in amyloid beta peptide 42 (J:87691)

• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

homeostasis/metabolism

amyloid beta deposits ( J:87691 , J:104236 )

• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)

• 150% increase in amyloid beta peptide 42 (J:87691)

• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:123534
Alzheimer's disease 3	DOID:0110042	OMIM:607822	J:123534
Alzheimer's disease 4	DOID:0110040	OMIM:606889	J:123534

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1)S8-4Dbo/0
Genetic Background	involves: C57BL/6J * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1)S8-4Dbo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:43788 )

N	• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 9 or 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0

Allelic Composition	Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
Tg(PSEN1dE9)S9Dbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal microglial cell morphology ( J:139070 )

• increase in microglial cell activity in retina is observed in 12-15 month old transgenics

• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control

• microglia density, but not cell body size, is increased in transgenics

amyloid beta deposits ( J:139070 )

• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age

• plaques have radial branches with a central core

• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months

• plaques appear earlier in females than in males and increase in number over time

• 100% of females and 75% of males have plaques in retina by 15-16 months

abnormal amacrine cell morphology ( J:139070 )

• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining

vision/eye

abnormal retina morphology ( J:139070 )

• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age

• most plaques (34.7% and 41% respectively) are found in the inner and outer plexiform layers

• thickness of the retinal nuclear layers is similar to control, suggesting that there is no obvious neuronal cell loss

abnormal amacrine cell morphology ( J:139070 )

• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining

abnormal retina inner plexiform layer morphology ( J:139070 )

• thioflavine-S positive plaques are first observed in females in the IPL at 12 months

• plaques are first observed in males at 13 months

• plaques are embedded within IPL cholinergic bands

abnormal retina outer plexiform layer morphology ( J:139070 )

• thioflavine-S positive plaques are first observed in females in the OPL at 12 months

• plaques are first observed in males at 13 months

abnormal eye electrophysiology ( J:139070 )

• amplitudes of a and b waves are decreased in 12-16 month old mice when tested at lower light intensity, but not a higher intensity

• latency and implicit time as determined by ERG measurement are similar to control

immune system

abnormal microglial cell morphology ( J:139070 )

• increase in microglial cell activity in retina is observed in 12-15 month old transgenics

• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control

• microglia density, but not cell body size, is increased in transgenics

hematopoietic system

abnormal microglial cell morphology ( J:139070 )

• increase in microglial cell activity in retina is observed in 12-15 month old transgenics

• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control

• microglia density, but not cell body size, is increased in transgenics

homeostasis/metabolism

amyloid beta deposits ( J:139070 )

• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age

• plaques have radial branches with a central core

• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months

• plaques appear earlier in females than in males and increase in number over time

• 100% of females and 75% of males have plaques in retina by 15-16 months

Allelic Composition	Tg(APP695)3Dbo/0
Genetic Background	B6.C3-Tg(APP695)3Dbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:109847 )

• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations

• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice

• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:109847 )

• at 24 months, males display a mild deterioration of sensorimotor abilities

increased startle reflex ( J:109847 )

• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type

abnormal locomotor behavior ( J:109847 )

• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task

homeostasis/metabolism

amyloid beta deposits ( J:109847 )

• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations

• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice

• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease	DOID:10652		J:109847
Alzheimer's disease 4	DOID:0110040	OMIM:606889	J:109847

Allelic Composition	Tg(APP695)3Dbo/0
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:43788 )

N	• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0

amyloid beta deposits ( J:43788 , J:87691 )

• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)

• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

homeostasis/metabolism

amyloid beta deposits ( J:43788 , J:87691 )

• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)

• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:87691

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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