All Phenotypes Nqo2<tm1Akj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nqo2^tm1Akj
targeted mutation 1, Anil K Jaiswal
MGI:2447336

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nqo2^tm1Akj/Nqo2^tm1Akj	Not Specified	MGI:3522037

Allelic Composition	Nqo2^tm1Akj/Nqo2^tm1Akj
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nqo2^tm1Akj mutation (0 available); any Nqo2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin tumor incidence ( J:92400 )

• in two stage tests increased sensitivity to chemically induced tumors

hematopoietic system

abnormal lymphopoiesis ( J:80549 )

• reduced numbers of circulating lymphocytes

increased granulocyte number ( J:80549 )

thrombocytosis ( J:80549 )

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:80549 )

• less susceptible to vitamin K3 toxicity (menadione)

immune system

abnormal lymphopoiesis ( J:80549 )

• reduced numbers of circulating lymphocytes

increased granulocyte number ( J:80549 )

integument

increased skin tumor incidence ( J:92400 )

• in two stage tests increased sensitivity to chemically induced tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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