All Phenotypes Gnaz<tm1Lfb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnaz^tm1Lfb
targeted mutation 1, Lawrence F Brass
MGI:2447341

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnaz^tm1Lfb/Gnaz^tm1Lfb	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	MGI:3615497
cn2	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438084
cn3	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438085

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:77282 )

• homozygotes display an enhanced cocaine-induced locomotor response

impaired behavioral response to addictive substance ( J:77282 )

• strikingly, homozygotes exhibit complete loss of the antidepressant effects of desipramine and reboxetine in the forced swimming test

decreased chemically-elicited antinociception ( J:77282 )

• homozygotes display reduced analgesia from morphine

hematopoietic system

decreased platelet aggregation ( J:77282 )

• homozygotes exhibit impaired platelet aggregation by failing to suppress cAMP formation when adenylyl cyclase is stimulated by PGI2

homeostasis/metabolism

decreased platelet aggregation ( J:77282 )

• homozygotes exhibit impaired platelet aggregation by failing to suppress cAMP formation when adenylyl cyclase is stimulated by PGI2

decreased susceptibility to induced thrombosis ( J:77282 )

• homozygotes show increased resistance to the fatal thromboembolic effects of collagen plus epinephrine

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (18 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with 20% frequency at 14.5 days post coitus; no embryos

Allelic Composition	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

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