All Phenotypes Gnaz<tm1Lfb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnaz^tm1Lfb
targeted mutation 1, Lawrence F Brass
MGI:2447341

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnaz^tm1Lfb/Gnaz^tm1Lfb	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	MGI:3615497
cn2	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438084
cn3	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438085

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:77282 )

• homozygotes display an enhanced cocaine-induced locomotor response

impaired behavioral response to addictive substance ( J:77282 )

• strikingly, homozygotes exhibit complete loss of the antidepressant effects of desipramine and reboxetine in the forced swimming test

decreased chemically-elicited antinociception ( J:77282 )

• homozygotes display reduced analgesia from morphine

hematopoietic system

decreased platelet aggregation ( J:77282 )

• homozygotes exhibit impaired platelet aggregation by failing to suppress cAMP formation when adenylyl cyclase is stimulated by PGI2

homeostasis/metabolism

decreased platelet aggregation ( J:77282 )

• homozygotes exhibit impaired platelet aggregation by failing to suppress cAMP formation when adenylyl cyclase is stimulated by PGI2

decreased susceptibility to induced thrombosis ( J:77282 )

• homozygotes show increased resistance to the fatal thromboembolic effects of collagen plus epinephrine

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (18 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with 20% frequency at 14.5 days post coitus; no embryos

Allelic Composition	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13