Phenotypes associated with this allele

• Allele Symbol: Tg(hAGT)2041Sig
• Allele Name: transgene insertion 2041, Curt Sigmund
• Allele ID: MGI:2447399
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hprt1^tm1(AGT)Sig/Hprt1^tm1(AGT)Sig Tg(hAGT)2041Sig/?	involves: 129P2/OlaHsd * C57BL/6 * SJL/J	MGI:3720715
cx2	Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig Tg(hAGT)2041Sig/?	involves: 129P2/OlaHsd * C57BL/6 * SJL/J	MGI:3720717
cx3	Hprt1^tm2(AGT)Sig/Y Tg(hAGT)2041Sig/?	involves: 129P2/OlaHsd * C57BL/6 * SJL/J	MGI:3720718
cx4	Tg(hAGT)2041Sig/0 Tg(hREN)9Sig/0	involves: C3H/HeRos * C57BL/6 * C57BL/10Ros * SJL/J	MGI:3800410
cx5	Tg(hAGT)2041Sig/0 Tg(hREN)9Sig/0	involves: C3H/HeRos * C57BL/6J * C57BL/10Ros * SJL/J	MGI:3800182
tg6	Tg(hAGT)2041Sig/0	involves: C57BL/6 * SJL/J	MGI:3800409

Genotype
MGI:3720715

cx1

• Allelic Composition: Hprt1^tm1(AGT)Sig/Hprt1^tm1(AGT)Sig; Tg(hAGT)2041Sig/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:81310 )

♀N • blood pressure and heart size are normal

Genotype
MGI:3720717

cx2

• Allelic Composition: Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig; Tg(hAGT)2041Sig/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL/J

cardiovascular system

increased heart weight ( J:81310 )

♀ • females exhibit an increase in heart weight-to-body weight relative to controls

growth/size/body

increased heart weight ( J:81310 )

♀ • females exhibit an increase in heart weight-to-body weight relative to controls

Genotype
MGI:3720718

cx3

• Allelic Composition: Hprt1^tm2(AGT)Sig/Y; Tg(hAGT)2041Sig/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL/J

cardiovascular system

increased systemic arterial blood pressure ( J:81310 )

♂ • males exhibit an increase in blood pressure of 9.7+/-0.9 mmHg compared to control littermates

Genotype
MGI:3800410

cx4

• Allelic Composition: Tg(hAGT)2041Sig/0; Tg(hREN)9Sig/0
• Genetic Background: involves: C3H/HeRos * C57BL/6 * C57BL/10Ros * SJL/J

cardiovascular system

increased mean systemic arterial blood pressure ( J:79859 )

increased systemic arterial diastolic blood pressure ( J:79859 )

increased systemic arterial systolic blood pressure ( J:79859 )

nervous system

abnormal baroreceptor physiology ( J:79859 )

• mice exhibit a resetting of the baroreflex control of heart rate to a higher pressure without changing the gain or sensitivity of the reflex

Genotype
MGI:3800182

cx5

• Allelic Composition: Tg(hAGT)2041Sig/0; Tg(hREN)9Sig/0
• Genetic Background: involves: C3H/HeRos * C57BL/6J * C57BL/10Ros * SJL/J

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:130409 )

• following treatment with L-NAME and a high salt diet, all mice die

• mice on a high salt diet exhibit increased lethality associated with brain hemorrhages

cardiovascular system

aortic aneurysm ( J:130409 )

• 2 mice treated with both L-NAME and a high salt diet exhibited a dissecting aortic aneurysm in addition to hemorrhagic stroke unlike similarly treated wild-type mice

increased heart weight ( J:130409 )

• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice

intracranial hemorrhage ( J:130409 )

• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice

brainstem hemorrhage ( J:130409 )

• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet

cerebellum hemorrhage ( J:130409 )

• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet

increased mean systemic arterial blood pressure ( J:130409 )

• following treatment with L-NAME and a high salt diet

increased systemic arterial systolic blood pressure ( J:130409 )

• following treatment with a high salt diet, mice exhibit an increase in systolic blood pressure not observed in similarly treated wild-type mice

• mice exhibit a higher systolic blood pressure than wild-type mice

nervous system

intracranial hemorrhage ( J:130409 )

• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice

brainstem hemorrhage ( J:130409 )

• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet

cerebellum hemorrhage ( J:130409 )

• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet

increased susceptibility to ischemic brain injury ( J:130409 )

• following treatment with L-NAME and a high salt diet

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:130409 )

• following treatment with L-NAME and a high salt diet

growth/size/body

increased heart weight ( J:130409 )

• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice

Genotype
MGI:3800409

tg6

• Allelic Composition: Tg(hAGT)2041Sig/0
• Genetic Background: involves: C57BL/6 * SJL/J

cardiovascular system

cardiovascular system phenotype ( J:79859 )

N • mice exhibit normal blood pressure

increased mean systemic arterial blood pressure ( J:79944 )

• upon treatment with human renin