Phenotypes associated with this allele

• Allele Symbol: Apoe^tm1Khw
• Allele Name: targeted mutation 1, Karl H Weisgraber
• Allele ID: MGI:2447429
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^tm1Khw/Apoe^tm1Khw	involves: 129S4/SvJae * C57BL/6	MGI:3818179
cx2	Apoe^tm1Khw/Apoe^tm1Khw Tg(Mx1-cre)29-4Her/0	B6.Cg-Apoe^tm1Khw Tg(Mx1-cre)29-4Her	MGI:5499989
cx3	Apoe^tm1Khw/Apoe^tm1Khw Tg(Mx1-cre)29-4Her/?	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3818180

Genotype
MGI:3818179

hm1

• Allelic Composition: Apoe^tm1Khw/Apoe^tm1Khw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:75681 )

• slight elevation of total plasma cholesterol on a normal diet

• slight increase in IDL on a normal diet

• substantial increase in plasma cholesterol on a high fat diet, reversible after three weeks on a normal diet

increased circulating LDL cholesterol level ( J:75681 )

• slight on a normal diet

increased circulating VLDL cholesterol level ( J:75681 )

• slightly on a normal diet

increased circulating triglyceride level ( J:75681 )

• slight increase on a normal diet

• substantial increase on a high fat diet, reversible after three weeks on a normal diet

Genotype
MGI:5499989

cx2

• Allelic Composition: Apoe^tm1Khw/Apoe^tm1Khw; Tg(Mx1-cre)29-4Her/0
• Genetic Background: B6.Cg-Apoe^tm1Khw Tg(Mx1-cre)29-4Her

homeostasis/metabolism

abnormal circulating lipid level ( J:196923 )

• mice fed a high cholesterol diet exhibit increased in all lipid classes, phospholipid, free cholesterol, cholesterol esters and triglycerides in the VLDL fractions compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

increased circulating cholesterol level ( J:196923 )

• at least 2-fold in mice fed a high cholesterol diet

• modest increase in female, but not male, mice fed a high cholesterol diet at 4 and 12 weeks compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

increased circulating VLDL cholesterol level ( J:196923 )

• in mice fed a high cholesterol diet compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

hyperlipidemia ( J:196923 )

• female mice fed a high cholesterol diet develop hypercholesterolemia faster than male mice

abnormal apolipoprotein level ( J:196923 )

• macrophages release reduced ApoE compared with macrophages from Apoe^tm1Rraf homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:196923 )

• in the descending aorta of mice fed a high cholesterol diet compared with Apoe^tm1Rraf homozygotes fed a high cholesterol diet

• however, lesion formation in the aortic arch is equivalent

immune system

immune system phenotype ( J:196923 )

N • leukocyte levels are not altered

Genotype
MGI:3818180

cx3

• Allelic Composition: Apoe^tm1Khw/Apoe^tm1Khw; Tg(Mx1-cre)29-4Her/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

homeostasis/metabolism

increased circulating cholesterol level ( J:75681 )

• substantial increase in plasma cholesterol on a high fat diet, reversible after cre induction with pIpC

increased circulating LDL cholesterol level ( J:75681 )

• slight on a normal diet

increased circulating VLDL cholesterol level ( J:75681 )

• slightly on a normal diet

increased circulating triglyceride level ( J:75681 )

• slight increase on a normal diet

• substantial increase on a high fat diet, reversible after cre induction using pIpC