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Allele Symbol Allele Name Allele ID |
Tsg101tm1Kuw targeted mutation 1, Kay-Uwe Wagner MGI:2447442 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Tsg101 transgene expression rescues mammary epithelial cells
• overexpression of Tsg101 supports expansion of secretory alveolar lobules relative to conditional Tsg101 knockouts, and tissue no longer shows mosaic pattern like non Tsg101-transgenics
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene
• some regions of the mammary gland are severely underdeveloped
• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation
• a subset of females, where recombination was inefficient are able to lactate
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• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene
• some regions of the mammary gland are severely underdeveloped
• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation
• a subset of females, where recombination was inefficient are able to lactate
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe inhibition of normal mammary gland development
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• alveolar development is severely impaired
• mutants unable to initiate lactation exhibit alveolar compartment regression after several days
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• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies
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• severe inhibition of normal mammary gland development
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• alveolar development is severely impaired
• mutants unable to initiate lactation exhibit alveolar compartment regression after several days
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• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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