Phenotypes associated with this allele

• Allele Symbol: Cd79a^tm2Cgn
• Allele Name: targeted mutation 2, University of Cologne
• Allele ID: MGI:2447454
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm2Cgn/Cd79a^tm2Cgn	involves: C57BL/6	MGI:3813545
hm2	Cd79a^tm2Cgn/Cd79a^tm2Cgn	involves: C57BL/6 * C.B-20	MGI:3687259
cx3	Cd79a^tm2Cgn/Cd79a^tm2Cgn Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz	involves: 129/Sv * C57BL/6	MGI:3813610

Genotype
MGI:3813545

hm1

• Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

decreased mature B cell number ( J:66840 , J:71100 )

• the number of mature B cells found in the spleen is reduced by about 100-fold (J:66840)

• there is a 100-fold reduction in the number of recirculating mature B cells in the bone marrow and spleen (J:71100)

decreased pre-B cell number ( J:66840 , J:71100 )

• mice have a 50% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-B cells in the bone marrow (J:66840)

• few B cells progress through the IgM⁺B220⁺CD43^- immature stage (J:66840)

• there is a 10-fold reduction in the number of pre-B cells (B220^low CD43^- IgM^- ) found in bone marrow (J:71100)

• there is a 10-fold reduction in the number of immature-B cells (B220^low IgM⁺ IgD^-) found in bone marrow (J:71100)

immune system

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

decreased mature B cell number ( J:66840 , J:71100 )

• the number of mature B cells found in the spleen is reduced by about 100-fold (J:66840)

• there is a 100-fold reduction in the number of recirculating mature B cells in the bone marrow and spleen (J:71100)

decreased pre-B cell number ( J:66840 , J:71100 )

• mice have a 50% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-B cells in the bone marrow (J:66840)

• few B cells progress through the IgM⁺B220⁺CD43^- immature stage (J:66840)

• there is a 10-fold reduction in the number of pre-B cells (B220^low CD43^- IgM^- ) found in bone marrow (J:71100)

• there is a 10-fold reduction in the number of immature-B cells (B220^low IgM⁺ IgD^-) found in bone marrow (J:71100)

Genotype
MGI:3687259

hm2

• Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn
• Genetic Background: involves: C57BL/6 * C.B-20

hematopoietic system

decreased B cell number ( J:80885 )

• marked reduction of a B220-hi/IgM+ mature B cell population in bone marrow and peripheral lymphoid compartments

• B cell numbers in the spleen and in the bone marrow were reduced to 1% of controls which do not increase in number with age

• the newly generated B cell compartment in the bone marrow is reduced to between one-quarter and one-third of the controls

decreased mature B cell number ( J:80885 )

• marked reduction of a B220-hi/IgM+ mature B cell population in bone marrow and peripheral lymphoid compartments

decreased immunoglobulin level ( J:80885 )

• the concentrations of serum immunoglobulin were generally reduced to between 10 and 25% of control

• the distribution of immunoglobulin isotypes in the sera was similar to that in wild-type

immune system

decreased B cell number ( J:80885 )

• marked reduction of a B220-hi/IgM+ mature B cell population in bone marrow and peripheral lymphoid compartments

• B cell numbers in the spleen and in the bone marrow were reduced to 1% of controls which do not increase in number with age

• the newly generated B cell compartment in the bone marrow is reduced to between one-quarter and one-third of the controls

decreased mature B cell number ( J:80885 )

• marked reduction of a B220-hi/IgM+ mature B cell population in bone marrow and peripheral lymphoid compartments

decreased immunoglobulin level ( J:80885 )

• the concentrations of serum immunoglobulin were generally reduced to between 10 and 25% of control

• the distribution of immunoglobulin isotypes in the sera was similar to that in wild-type

Genotype
MGI:3813610

cx3

• Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn; Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz
• Genetic Background: involves: 129/Sv * C57BL/6

immune system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains

hematopoietic system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains