Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Ncoa6)54Hwl
• Allele Name: transgene insertion 54, Han-Woong Lee
• Allele ID: MGI:2447467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Ncoa6)54Hwl/0	involves: FVB	MGI:6276323

Genotype
MGI:6276323

tg1

• Allelic Composition: Tg(CAG-Ncoa6)54Hwl/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye morphology ( J:80609 )

• eyes show a persistent connection between the optic nerve and projected posterior segment

abnormal lens capsule morphology ( J:80609 )

• defective posterior lens capsule

abnormal lens development ( J:80609 )

• abnormal lens development, with impaired normal proliferation and differentiation process of embryonic lens cells

cataract ( J:80609 )

• unilateral or bilateral cataracts in embryos and adults

lenticonus ( J:80609 )

• adults exhibit posterior lenticonus with numerous vacuolations, covered by relatively intact migration of equatorial epithelial cells but defective posterior lens capsule

persistent hyperplastic primary vitreous ( J:80609 )

• mice show the presence of the retrolenticular membrane indicating that the primary vitreous membrane does not regress and develops to fuse to the posterior capsule of the lens in adulthood

microphthalmia ( J:80609 )

• in embryos and adults

narrow eye opening ( J:80609 )

• size of the palpebral fissure is reduced

abnormal retina morphology ( J:80609 )

• retinal dysplasia with presence of retinal folds in embryos and adults

disorganized retina layers ( J:80609 )

• retinas exhibit marked disorganization of cellular layer patterns of the neural retina

retina fold ( J:80609 )

• retinal folds are present in embryos and adults

sclera thinning ( J:80609 )

• sclera is locally thinner or missing in embryos and adults

behavior/neurological

impaired coordination ( J:80609 )

• mice show motor defects on the rotarod

cardiovascular system

cardiovascular system phenotype ( J:80609 )

N • mice do not exhibit heart defects