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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-Pim1)1Brn
transgene insertion 1, Anton Berns
MGI:2447531
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0 		either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N) MGI:3698152
cx2
 		Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0 		involves: 129P2/OlaHsd * C57BL/6LiA * CBA MGI:3698156
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(Igh-Pim1)1Brn/0 		involves: 129S/SvEv * C57BL/6LiA * CBA MGI:3698155
tg4
 		Tg(Igh-Pim1)1Brn/0 involves: C57BL/6LiA * CBA MGI:3691592


Genotype
MGI:3698152
cx1
Allelic
Composition		 Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation (0 available); any Il2rg mutation (179 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)




Genotype
MGI:3698156
cx2
Allelic
Composition		 Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3gtm1Amk mutation (0 available); any Cd3g mutation (27 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice




Genotype
MGI:3698155
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age




Genotype
MGI:3691592
tg4
Allelic
Composition		 Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens

immune system
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens
enlarged lymph nodes ( J:79624 )
• mice with lymphoma show enlarged lymph nodes

neoplasm

endocrine/exocrine glands
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged

growth/size/body
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory