About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-Pim1)1Brn
transgene insertion 1, Anton Berns
MGI:2447531
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0 		either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N) MGI:3698152
cx2
 		Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0 		involves: 129P2/OlaHsd * C57BL/6LiA * CBA MGI:3698156
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(Igh-Pim1)1Brn/0 		involves: 129S/SvEv * C57BL/6LiA * CBA MGI:3698155
tg4
 		Tg(Igh-Pim1)1Brn/0 involves: C57BL/6LiA * CBA MGI:3691592


Genotype
MGI:3698152
cx1
Allelic
Composition		 Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation (0 available); any Il2rg mutation (179 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)




Genotype
MGI:3698156
cx2
Allelic
Composition		 Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3gtm1Amk mutation (0 available); any Cd3g mutation (27 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice




Genotype
MGI:3698155
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 5-15 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age




Genotype
MGI:3691592
tg4
Allelic
Composition		 Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens

immune system
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens
enlarged lymph nodes ( J:79624 )
• mice with lymphoma show enlarged lymph nodes

neoplasm

endocrine/exocrine glands
enlarged thymus ( J:79624 )
• in transgenic mice with tumors, thymus is often enlarged

growth/size/body
enlarged spleen ( J:79624 )
• mice with lymphoma display grossly enlarged spleens




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory