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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SFTPC-RAF1-BxB)1Urr
transgene insertion 1, Ulf R Rapp
MGI:2447567
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2 MGI:2653483
cx2
 		Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2 MGI:3693213
cx3
 		Bcl2tm1Mpin/Bcl2+
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:2653486
cx4
 		Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:3693212
cx5
 		Bag1tm1Msd/Bag1+
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: C57BL/6 MGI:3529140
tg6
 		Tg(SFTPC-RAF1-BxB)1Urr/0 involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:2653484
tg7
 		Tg(SFTPC-RAF1-BxB)1Urr/0 involves: C57BL/6 * DBA/2 MGI:3693205


Genotype
MGI:2653483
cx1
Allelic
Composition		 Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (41 available)
Tg(H2-K-BCL2)1Josd mutation (0 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:79696 )
• exhibit rapid adenoma development

respiratory system
increased lung adenoma incidence ( J:79696 )
• exhibit rapid adenoma development




Genotype
MGI:3693213
cx2
Allelic
Composition		 Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:79696 )
• 100% develop tumors by 1 month of age

respiratory system
increased lung adenoma incidence ( J:79696 )
• 100% develop tumors by 1 month of age




Genotype
MGI:2653486
cx3
Allelic
Composition		 Bcl2tm1Mpin/Bcl2+
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (41 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:79696 )
• 100% develop tumors by 1 month of age

respiratory system
increased lung adenoma incidence ( J:79696 )
• 100% develop tumors by 1 month of age




Genotype
MGI:3693212
cx4
Allelic
Composition		 Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (41 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:79696 )
• 40% develop lung tumors at 2.5 months of age
decreased tumor incidence ( J:79696 )
• although mutants develop lung adenomas, they show a 6-8 fold delay in tumor incidence compared to single transgenic Tg(SFTPC-RAF1-BxB)1Urr mice
• exhibit an increase in the number of apoptotic cells and a decrease in the number of proliferating cells in lung ademonas

respiratory system
increased lung adenoma incidence ( J:79696 )
• 40% develop lung tumors at 2.5 months of age




Genotype
MGI:3529140
cx5
Allelic
Composition		 Bag1tm1Msd/Bag1+
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag1tm1Msd mutation (0 available); any Bag1 mutation (21 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:95491 )
• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1

respiratory system
decreased lung tumor incidence ( J:95491 )
• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1




Genotype
MGI:2653484
tg6
Allelic
Composition		 Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:79696 )
• 100% develop lung tumors by 1 month of age, showing decreased number of apoptotic cells and increased number of proliferating cells in lung adenomas

respiratory system
increased lung adenoma incidence ( J:79696 )
• 100% develop lung tumors by 1 month of age, showing decreased number of apoptotic cells and increased number of proliferating cells in lung adenomas




Genotype
MGI:3693205
tg7
Allelic
Composition		 Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenoma incidence ( J:80895 )
• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass
• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells
• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion

respiratory system
increased lung adenoma incidence ( J:80895 )
• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass
• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells
• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory