Analysis Tools
neoplasm
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• exhibit rapid adenoma development
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respiratory system
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• exhibit rapid adenoma development
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Allele Symbol Allele Name Allele ID |
Tg(SFTPC-RAF1-BxB)1Urr transgene insertion 1, Ulf R Rapp MGI:2447567 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit rapid adenoma development
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• exhibit rapid adenoma development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% develop tumors by 1 month of age
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• 100% develop tumors by 1 month of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% develop tumors by 1 month of age
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• 100% develop tumors by 1 month of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% develop lung tumors at 2.5 months of age
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• although mutants develop lung adenomas, they show a 6-8 fold delay in tumor incidence compared to single transgenic Tg(SFTPC-RAF1-BxB)1Urr mice
• exhibit an increase in the number of apoptotic cells and a decrease in the number of proliferating cells in lung ademonas
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• 40% develop lung tumors at 2.5 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% develop lung tumors by 1 month of age, showing decreased number of apoptotic cells and increased number of proliferating cells in lung adenomas
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• 100% develop lung tumors by 1 month of age, showing decreased number of apoptotic cells and increased number of proliferating cells in lung adenomas
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass
• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells
• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion
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• develop lung tumors within 1-2 months of age; confluent tumor development is observed within 5-7 months, accompanied by an 8-10-fold increase in lung tissue mass
• lesions are classified as multicentric alveolar adenomas developed from alveolar type II cells
• tumors consist of cuboid epithelial comparable to alveolar type II cells and show a glandular proliferation, lining the alveolar walls in a lepidic fashion
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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