All Phenotypes Tg(H2-K-BCL2)1Josd MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} Tg(H2-K-BCL2)1Josd/0	involves: 129 * C3H * C57BL/6	MGI:4443111
cn2	Il7r^tm2Iku/Il7r^tm2Iku Tg(Cd4-cre)1Cwi/? Tg(H2-K-BCL2)1Josd/?	involves: 129S6/SvEvTac * C57BL/6 * C3H * DBA/2	MGI:5475545
cx3	Bcl2^tm1Mpin/Bcl2^tm1Mpin Tg(H2-K-BCL2)1Josd/0 Tg(SFTPC-RAF1-BxB)1Urr/0	involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2	MGI:2653483
cx4	Tg(H2-K-BCL2)1Josd/0 Tg(SFTPC-RAF1-BxB)1Urr/0	involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2	MGI:3693213
tg5	Tg(H2-K-BCL2)1Josd/0	involves: C57BL/6 * C57BL/Ka * C3H	MGI:3693130

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} Tg(H2-K-BCL2)1Josd/0
Genetic Background	involves: 129 * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(H2-K-BCL2)1Josd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system physiology ( J:158953 )

• GFP+ hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice

Allelic Composition	Il7r^tm2Iku/Il7r^tm2Iku Tg(Cd4-cre)1Cwi/? Tg(H2-K-BCL2)1Josd/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C3H * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7r^tm2Iku mutation (0 available); any Il7r mutation (31 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(H2-K-BCL2)1Josd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:193283 )

N	• CD8+ numbers and CD8+/CD4+ ratio recovered from condition in mice lacking Tg(H2-K-BCL2)1Josd

Allelic Composition	Bcl2^tm1Mpin/Bcl2^tm1Mpin Tg(H2-K-BCL2)1Josd/0 Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2^tm1Mpin mutation (1 available); any Bcl2 mutation (41 available)
Tg(H2-K-BCL2)1Josd mutation (0 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung adenoma incidence ( J:79696 )

• exhibit rapid adenoma development

respiratory system

increased lung adenoma incidence ( J:79696 )

• exhibit rapid adenoma development

Allelic Composition	Tg(H2-K-BCL2)1Josd/0 Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung adenoma incidence ( J:79696 )

• 100% develop tumors by 1 month of age

respiratory system

increased lung adenoma incidence ( J:79696 )

• 100% develop tumors by 1 month of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing delayed death after irradiation compared to wild-type

hematopoietic system

abnormal hematopoietic system morphology/development ( J:80894 )

• hematopoietic populations, such as mature B- and T-cells, natural killer cells, myeloid cells, erythroid cells, and stem cells, show increased resistance to the effects of irradiation

enlarged thymus ( J:80894 )

enlarged spleen ( J:80894 )

increased leukocyte cell number ( J:80894 )

• increase in the number of circulating white blood cells

increased hematopoietic stem cell number ( J:80894 )

• increase in the number of hematopoietic stem cells

cellular

decreased cellular sensitivity to X-ray irradiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing an increase in the radioresistance of individual cells, and an increase in the size of certain critically important cell populations, such as the hematopoietic stem cells

immune system

increased leukocyte cell number ( J:80894 )

• increase in the number of circulating white blood cells

abnormal lymph organ size ( J:80894 )

• 2- to 5-fold increase in size of lymphoid organs

enlarged thymus ( J:80894 )

enlarged spleen ( J:80894 )

enlarged lymph nodes ( J:80894 )

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:80894 )

• exhibit increased resistance to lethal challenges of x-ray irradiation, showing delayed death after irradiation compared to wild-type

endocrine/exocrine glands

enlarged thymus ( J:80894 )

growth/size/body

enlarged spleen ( J:80894 )

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