All Phenotypes Tg(LCKprBCL2)36Sjk MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tg(Cd4-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?	involves: 129 * C57BL/6 * DBA/2	MGI:3767631
cn2	Il2rg^tm1.1Asin/Il2rg^tm1Wjl Tg(Cd8a*-cre)B8Asin/0 Tg(LCKprBCL2)36Sjk/0	involves: 129S4/SvJae * C57BL/6	MGI:5469013
cn3	Smarca4^tm1.2Pcn/Smarca4^tm1Mag Tg(Lck-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?	involves: 129S/Sv * C57BL/6 * DBA/2	MGI:2677148
cx4	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(LCKprBCL2)36Sjk/0	involves: C57BL/6 * C57BL/10	MGI:5661487
cx5	Tg(LCKprBCL2)36Sjk/0 Tg(Nr4a1-EGFP/cre)820Khog/0	involves: C57BL/6 * C57BL/6J	MGI:5661493
cx6	Tg(LCKprBCL2)36Sjk/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5661489
tg7	Tg(LCKprBCL2)36Sjk/0	B6.Cg-Tg(LCKprBCL2)36Sjk	MGI:5661485
tg8	Tg(LCKprBCL2)36Sjk/0	involves: C57BL/6 * CBA/J	MGI:5661496
tg9	Tg(LCKprBCL2)36Sjk/?	involves: C3H * C57BL/6	MGI:3799299

Allelic Composition	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tg(Cd4-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11b^tm1Avram mutation (0 available); any Bcl11b mutation (46 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

abnormal positive T cell selection ( J:128515 )

• slightly less apoptotic double positive T cells after 16 hours of culturing compared to transgenic mice that do not express Cre recombinase

decreased double-positive T cell number ( J:128515 )

• 93% reduction in number of double positive T cells

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

immune system

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

abnormal positive T cell selection ( J:128515 )

• slightly less apoptotic double positive T cells after 16 hours of culturing compared to transgenic mice that do not express Cre recombinase

decreased double-positive T cell number ( J:128515 )

• 93% reduction in number of double positive T cells

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

Allelic Composition	Il2rg^tm1.1Asin/Il2rg^tm1Wjl Tg(Cd8a*-cre)B8Asin/0 Tg(LCKprBCL2)36Sjk/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rg^tm1.1Asin mutation (1 available); any Il2rg mutation (178 available)
Il2rg^tm1Wjl mutation (83 available); any Il2rg mutation (178 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK T cell number ( J:190889 )

• of invariant NK T cells as in Il2rg^tm1.1Asin/Il2rg^tm1Wjl Tg(Cd8a*-cre)#Asin mice

hematopoietic system

decreased NK T cell number ( J:190889 )

• of invariant NK T cells as in Il2rg^tm1.1Asin/Il2rg^tm1Wjl Tg(Cd8a*-cre)#Asin mice

Allelic Composition	Smarca4^tm1.2Pcn/Smarca4^tm1Mag Tg(Lck-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?
Genetic Background	involves: 129S/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4^tm1.2Pcn mutation (1 available); any Smarca4 mutation (110 available)
Smarca4^tm1Mag mutation (1 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested T cell differentiation ( J:85191 )

• cells arrested in G1 phase of cell cycle leading to a 10 fold increase in cell numbers as opposed to animals lacking TgN(LCKprBCL2)36Sjk

immune system

arrested T cell differentiation ( J:85191 )

• cells arrested in G1 phase of cell cycle leading to a 10 fold increase in cell numbers as opposed to animals lacking TgN(LCKprBCL2)36Sjk

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(LCKprBCL2)36Sjk/0
Genetic Background	involves: C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio mutation (0 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

Allelic Composition	Tg(LCKprBCL2)36Sjk/0 Tg(Nr4a1-EGFP/cre)820Khog/0
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)
Tg(Nr4a1-EGFP/cre)820Khog mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

abnormal T cell clonal deletion ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

abnormal T cell clonal deletion ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

cellular

decreased thymocyte apoptosis ( J:217939 )

• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

Allelic Composition	Tg(LCKprBCL2)36Sjk/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

Allelic Composition	Tg(LCKprBCL2)36Sjk/0
Genetic Background	B6.Cg-Tg(LCKprBCL2)36Sjk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell subpopulation ratio ( J:217939 )

• the CD4 to CD8 T cell ratio is somewhat skewed in favor of CD8 T cells

abnormal CD4-positive, alpha-beta T cell number ( J:217939 )

• mice show a higher proportion of previously activated, anergic CD4 T cells

increased regulatory T cell number ( J:217939 )

• greater Foxp3+ Treg cell proportions and numbers in both the thymus and lymph nodes

immune system

abnormal T cell subpopulation ratio ( J:217939 )

• the CD4 to CD8 T cell ratio is somewhat skewed in favor of CD8 T cells

abnormal CD4-positive, alpha-beta T cell number ( J:217939 )

• mice show a higher proportion of previously activated, anergic CD4 T cells

increased regulatory T cell number ( J:217939 )

• greater Foxp3+ Treg cell proportions and numbers in both the thymus and lymph nodes

Allelic Composition	Tg(LCKprBCL2)36Sjk/0
Genetic Background	involves: C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating enhanced rescue of thymocytes from negative selection

abnormal T cell clonal deletion ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

abnormal T cell clonal deletion ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

cellular

decreased thymocyte apoptosis ( J:217939 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell apoptosis ( J:11548 )

• 30% of thymocytes survive 6 days in culture compared to less than 1% for thymocytes from wild-type mice due to less apoptosis

• similar results are seen for splenic cells

• apoptosis induced by dexamethasone only causes a10-20% reduction in the number of thymocytes compared to 90 to 98% in control mice

• thymocytes are also resistant to apoptosis induced by low-dose radiation

• thymocytes are resistant to apoptosis triggered by CD3 ligation

abnormal thymus cell ratio ( J:11548 )

• ratio of CD4 to CD8 single positive T cells is 1.3 in transgenic mice compared to 3.9 in wild-type mice

increased T cell derived lymphoma incidence ( J:28635 )

• 18 of 68 mice develop lymphoma at a mean age of 18 months compared to 1 wild-type mouse out of 56 developing lymphoma in the control group

• 15 of the 18 lymphomas are large cell lymphoma with several showing immunoblastic features

• the remaining 3 are diffuse small lymphocytic lymphoma

• the lymphomas usually present as a rapidly expanding mass in the mesenteric lymph nodes though they can also occur in the mediastinal or cervical nodes

• extranodal involvement in other tissues occurs frequently

• splenomegaly and ascites fluid are sometimes observed

abnormal T cell number ( J:28635 )

• at 12 months of age, there is a 3-4 fold increase in the absolute number of T cells in the spleen

• transgenic mice have 83 x 10⁶ T cells compared to 25 x 10⁶ T cells

abnormal T cell subpopulation ratio ( J:11548 )

• ratio of CD4 to CD8 T cells in the spleen is 1.4 compared to 2.6 in control mice

increased T cell number ( J:11548 )

• CD3^high/TCR^high cells make up 40% of thymocytes compared to 15% in non-transgenic controls

• there is a reciprocal decrease in CD3^lo cells in the thymus

• the number of T cells found in the spleen doubles

increased CD8-positive, alpha-beta T cell number ( J:11548 )

• the percentage of CD8 single positive T cells found in the thymus is almost double that in wild-type

• the percentage of CD8 T cells in the spleen is also doubled

neoplasm

increased T cell derived lymphoma incidence ( J:28635 )

• 18 of 68 mice develop lymphoma at a mean age of 18 months compared to 1 wild-type mouse out of 56 developing lymphoma in the control group

• 15 of the 18 lymphomas are large cell lymphoma with several showing immunoblastic features

• the remaining 3 are diffuse small lymphocytic lymphoma

• the lymphomas usually present as a rapidly expanding mass in the mesenteric lymph nodes though they can also occur in the mediastinal or cervical nodes

• extranodal involvement in other tissues occurs frequently

• splenomegaly and ascites fluid are sometimes observed

hematopoietic system

decreased T cell apoptosis ( J:11548 )

• 30% of thymocytes survive 6 days in culture compared to less than 1% for thymocytes from wild-type mice due to less apoptosis

• similar results are seen for splenic cells

• apoptosis induced by dexamethasone only causes a10-20% reduction in the number of thymocytes compared to 90 to 98% in control mice

• thymocytes are also resistant to apoptosis induced by low-dose radiation

• thymocytes are resistant to apoptosis triggered by CD3 ligation

abnormal thymus cell ratio ( J:11548 )

• ratio of CD4 to CD8 single positive T cells is 1.3 in transgenic mice compared to 3.9 in wild-type mice

increased T cell derived lymphoma incidence ( J:28635 )

• 18 of 68 mice develop lymphoma at a mean age of 18 months compared to 1 wild-type mouse out of 56 developing lymphoma in the control group

• 15 of the 18 lymphomas are large cell lymphoma with several showing immunoblastic features

• the remaining 3 are diffuse small lymphocytic lymphoma

• the lymphomas usually present as a rapidly expanding mass in the mesenteric lymph nodes though they can also occur in the mediastinal or cervical nodes

• extranodal involvement in other tissues occurs frequently

• splenomegaly and ascites fluid are sometimes observed

abnormal T cell number ( J:28635 )

• at 12 months of age, there is a 3-4 fold increase in the absolute number of T cells in the spleen

• transgenic mice have 83 x 10⁶ T cells compared to 25 x 10⁶ T cells

abnormal T cell subpopulation ratio ( J:11548 )

• ratio of CD4 to CD8 T cells in the spleen is 1.4 compared to 2.6 in control mice

increased T cell number ( J:11548 )

• CD3^high/TCR^high cells make up 40% of thymocytes compared to 15% in non-transgenic controls

• there is a reciprocal decrease in CD3^lo cells in the thymus

• the number of T cells found in the spleen doubles

increased CD8-positive, alpha-beta T cell number ( J:11548 )

• the percentage of CD8 single positive T cells found in the thymus is almost double that in wild-type

• the percentage of CD8 T cells in the spleen is also doubled

cellular

decreased T cell apoptosis ( J:11548 )

• 30% of thymocytes survive 6 days in culture compared to less than 1% for thymocytes from wild-type mice due to less apoptosis

• similar results are seen for splenic cells

• apoptosis induced by dexamethasone only causes a10-20% reduction in the number of thymocytes compared to 90 to 98% in control mice

• thymocytes are also resistant to apoptosis induced by low-dose radiation

• thymocytes are resistant to apoptosis triggered by CD3 ligation

endocrine/exocrine glands

abnormal thymus cell ratio ( J:11548 )

• ratio of CD4 to CD8 single positive T cells is 1.3 in transgenic mice compared to 3.9 in wild-type mice

increased T cell derived lymphoma incidence ( J:28635 )

• 18 of 68 mice develop lymphoma at a mean age of 18 months compared to 1 wild-type mouse out of 56 developing lymphoma in the control group

• 15 of the 18 lymphomas are large cell lymphoma with several showing immunoblastic features

• the remaining 3 are diffuse small lymphocytic lymphoma

• the lymphomas usually present as a rapidly expanding mass in the mesenteric lymph nodes though they can also occur in the mediastinal or cervical nodes

• extranodal involvement in other tissues occurs frequently

• splenomegaly and ascites fluid are sometimes observed

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