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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspa2tm1Dix
targeted mutation 1, David J Dix
MGI:2447605
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hspa2tm1Dix/Hspa2tm1Dix either: 129S/SvEv or C57BL/6 MGI:2450069


Genotype
MGI:2450069
hm1
Allelic
Composition		 Hspa2tm1Dix/Hspa2tm1Dix
Genetic
Background		 either: 129S/SvEv or C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa2tm1Dix mutation (1 available); any Hspa2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased testis weight ( J:35110 )
• testes of adult mutant males were significantly lower in weight as compared to heterozygous and wild-type controls
• epididymal and seminal vesicle weights were comparable to controls

reproductive system
abnormal male meiosis ( J:35110 )
• most seminiferous tubules contained pachytene spermatocytes with condensed nuclei, some of which appeared fragmented and apoptotic
decreased testis weight ( J:35110 )
• testes of adult mutant males were significantly lower in weight as compared to heterozygous and wild-type controls
• epididymal and seminal vesicle weights were comparable to controls
arrest of spermatogenesis ( J:35110 )
• mice were deficient in postmeiotic spermatids and lacked spermatozoa in the epididymis

cellular
abnormal male meiosis ( J:35110 )
• most seminiferous tubules contained pachytene spermatocytes with condensed nuclei, some of which appeared fragmented and apoptotic




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory