All Phenotypes Mbd4<tm1Wed> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mbd4^tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:2447611

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd4^tm1Wed/Mbd4^tm1Wed	B6.Cg-Mbd4^tm1Wed/J	MGI:5292473
hm2	Mbd4^tm1Wed/Mbd4^tm1Wed	involves: 129/Sv * C57BL/6 * SJL	MGI:3719439
cx3	Apc^tm1Rak/Apc⁺ Mbd4^tm1Wed/Mbd4^tm1Wed	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL	MGI:3719440

Allelic Composition	Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	B6.Cg-Mbd4^tm1Wed/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:175891 )

• at E8.33, demethylation of the Hes5 promoter is impaired

Allelic Composition	Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:80319 )

• the occurrence of transition mutations in splenocytes is increased 3-fold and more than 2-fold in small intestinal epithelial cells

• CG to TA transitions occur more than twice as often compared to in wild-type mice

Allelic Composition	Apc^tm1Rak/Apc⁺ Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Rak mutation (1 available); any Apc mutation (158 available)
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Microadenoma in Mbd4^tm1Wed/Mbd4^tm1Wed Apc^tm1Rak/Apc⁺ gastrointestinal tract

neoplasm

increased gastrointestinal tumor incidence ( J:80319 )

• the multiplicity of gastro-intestinal tumors is increased 2.4 times relative to Apc^tm1Rak heterozygotes

• mice have greater number of tumors in the jejunum and ileum than in Apc^tm1Rak heterozygotes

• mice have 10-fold increase in microadenomas compared to Apc^tm1Rak heterozygotes

• tumor progression is accelerated relative to Apc^tm1Rak heterozygotes

cellular

abnormal cell physiology ( J:80319 )

• mice tumors have more CG to TA transition mutations in the Apc gene than in Apc^tm1Rak heterozygotes

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:80319 )

• the multiplicity of gastro-intestinal tumors is increased 2.4 times relative to Apc^tm1Rak heterozygotes

• mice have greater number of tumors in the jejunum and ileum than in Apc^tm1Rak heterozygotes

• mice have 10-fold increase in microadenomas compared to Apc^tm1Rak heterozygotes

• tumor progression is accelerated relative to Apc^tm1Rak heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24