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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm1Tani
targeted mutation 1, Ichiro Taniuchi
MGI:2447630
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Runx1tm1Tani/Runx1tm1Tani
Tg(Lck-cre)1Cwi/? 		involves: 129P2/OlaHsd MGI:3763097
cn2
 		Runx1tm1Tani/Runx1tm1Tani
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3763114
cn3
 		Runx1tm1Tani/Runx1tm1Tani
Tg(Cd4-cre)1Cwi/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3763100


Genotype
MGI:3763097
cn1
Allelic
Composition		 Runx1tm1Tani/Runx1tm1Tani
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Tani mutation (1 available); any Runx1 mutation (34 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development
increased double-negative T cell number ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stag
decreased double-positive T cell number ( J:125959 )
• resulting from arrested T cell development
arrested T cell differentiation ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stage

hematopoietic system
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development
increased double-negative T cell number ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stag
decreased double-positive T cell number ( J:125959 )
• resulting from arrested T cell development
arrested T cell differentiation ( J:125959 )
• developing T cells fail to make the transition between DN3 to DN4 stage

endocrine/exocrine glands
decreased thymocyte number ( J:125959 )
• six fold less cells as a result of arrested T cell development




Genotype
MGI:3763114
cn2
Allelic
Composition		 Runx1tm1Tani/Runx1tm1Tani
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Tani mutation (1 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:125959 )
• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:125959 )
• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession




Genotype
MGI:3763100
cn3
Allelic
Composition		 Runx1tm1Tani/Runx1tm1Tani
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Tani mutation (1 available); any Runx1 mutation (34 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:125959 )
• reduced level of mature CD4-positive T cells in thymus
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125959 )
• reduced level of mature CD8-postive T cells in the thymus
abnormal double-positive T cell morphology ( J:125959 )
• lower expression of TCRbeta
decreased CD4-positive, alpha-beta T cell number ( J:125959 )
• severely reduced numbers in the spleen and lymph nodes resulting from decreased survival

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:125959 )
• reduced level of mature CD4-positive T cells in thymus
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125959 )
• reduced level of mature CD8-postive T cells in the thymus
abnormal double-positive T cell morphology ( J:125959 )
• lower expression of TCRbeta
decreased CD4-positive, alpha-beta T cell number ( J:125959 )
• severely reduced numbers in the spleen and lymph nodes resulting from decreased survival




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory