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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnj3tm1Kwn
targeted mutation 1, Kevin D Wickman
MGI:2447632
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnj3tm1Kwn/Kcnj3tm1Kwn involves: 129X1/SvJ MGI:3041949


Genotype
MGI:3041949
hm1
Allelic
Composition		 Kcnj3tm1Kwn/Kcnj3tm1Kwn
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj3tm1Kwn mutation (1 available); any Kcnj3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart rate ( J:80714 )
• homozygous null mice were viable, fertile and grossly normal but displayed a modest resting tachycardia, compared with wild-type littermates
abnormal myocardial fiber physiology ( J:80714 )
• atrial myocytes from mutant mice exhibited a severe reduction in G protein-gated potassium current
• mutant mice displayed blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory