Phenotypes associated with this allele

• Allele Symbol: Tg(NOS3)3Crom
• Allele Name: transgene insertion 3, Rini de Crom
• Allele ID: MGI:2447660
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(NOS3)3Crom/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:2653579
tg2	Tg(NOS3)3Crom/0	involves: C57BL/6 * FVB	MGI:2653576

Genotype
MGI:2653579

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(NOS3)3Crom/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:80701 )

• decrease in atherosclerosis compared to single Apoe homozygotes

decreased systemic arterial blood pressure ( J:80701 )

• mutants fed a Western Diet show a decrease in systemic blood pressure although heart rate is normal

homeostasis/metabolism

decreased circulating cholesterol level ( J:80701 )

• ~15-16% decrease in plasma cholesterol on a normal chow diet or Western diet compared to single Apoe homozygotes

Genotype
MGI:2653576

tg2

• Allelic Composition: Tg(NOS3)3Crom/0
• Genetic Background: involves: C57BL/6 * FVB

cardiovascular system

decreased systemic vascular resistance ( J:80701 )

• 30% lower systemic vascular resistance; lower mean aortic blood pressure but normal mean aortic blood flow and heart rate

decreased mean systemic arterial blood pressure ( J:80701 )

• 20-25 mm Hg lower mean aortic blood pressure compared to controls