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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mpz)80.3Wra
transgene insertion 80.3, Lawrence Wrabetz
MGI:2447696
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Mpz)80.3Wra/Tg(Mpz)80.3Wra involves: FVB/N MGI:2653554
tg2
Tg(Mpz)80.3Wra/0 involves: FVB/N MGI:4399152


Genotype
MGI:2653554
tg1
Allelic
Composition
Tg(Mpz)80.3Wra/Tg(Mpz)80.3Wra
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• P28 mutants exhibit tremors

nervous system
• dysmyelination is observed in P28 mutants
• ventral roots are more dysmyelinated than dorsal roots




Genotype
MGI:4399152
tg2
Allelic
Composition
Tg(Mpz)80.3Wra/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• sciatic nerves are hypomyelinated between P15 and P21, but by P28, nerves contain normal myelin
• ventral roots are more dysmyelinated than dorsal roots

behavior/neurological
N
• mice appear behaviorally normal and show no tremors

mortality/aging
N
• mice have a median life span of more than 2 years





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory