All Phenotypes Tg(Mpz)80.4Wra MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mpz)80.4Wra
transgene insertion 80.4, Lawrence Wrabetz
MGI:2447698

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mpz^tm1Msch/Mpz^tm1Msch Tg(Mpz)80.4Wra/0	involves: 129S7/SvEvBrd * FVB/N	MGI:2653555
tg2	Tg(Mpz)80.4Wra/0	involves: FVB/N	MGI:2653551

Allelic Composition	Mpz^tm1Msch/Mpz^tm1Msch Tg(Mpz)80.4Wra/0
Genetic Background	involves: 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpz^tm1Msch mutation (0 available); any Mpz mutation (28 available)
Tg(Mpz)80.4Wra mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:78758 )

N	• normal myelination

Allelic Composition	Tg(Mpz)80.4Wra/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

dysmyelination ( J:78758 )

• mutants exhibit a mixture of hyper- and hypomyelinated fibers

• dysmyelination with about 50% of the large axons ensheathed by single Swann cells that have not formed myelin

decreased nerve conduction velocity ( J:78758 )

• nerve conduction velocity is reduced to 11 m/s

mortality/aging

premature death ( J:78758 )

• median life span is 10 months

behavior/neurological

tremors ( J:78758 )

• mild tremor

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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